Robert C. DeNovo

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OBJECTIVE To determine whether substantial interobserver variation exists among diagnostic pathologists for descriptions of intestinal mucosal cell populations and whether histopathologic descriptions accurately predict when a patient does not have clinically evident intestinal disease. DESIGN Comparative survey. Sample Population-14 histologic slides of(More)
A double-blind study was conducted to compare gastric ulcer healing time in nontreated dogs with that in dogs treated with either cimetidine or omeprazole. Single ulcers were created in the gastric antrum by use of a suction biopsy capsule. Each dog was given 25 mg of aspirin/kg of body weight orally for 20 days after ulcer induction. Five control dogs were(More)
An acousto-optic tunable filter (AOTF)-based system for dual-modality hyperspectral imaging (DMHSI) has been developed for use in characterization of normal and malignant mouse tissue. The system consists of a laser, endoscope, AOTF, and two cameras coupled with optics and electronics. Initial results show that the system can delineate normal and malignant(More)
Wedge biopsy of the liver during episodic clinical illness in three male cats showed lymphocytic cholangitis. Principal clinical findings were increased serum alkaline phosphatase activity and hepatomegaly (two cats) associated with anorexia, pyrexia. and weight loss; these signs of illness were intermittent with asymptomatic periods. The hepatic lesions(More)
Disseminated histoplasmosis was diagnosed in a 10-year-old dog suspected of having hepatic carcinoma. Clinical abnormalities included diffuse hepatomegaly, gastrointestinal bleeding, thoracic and abdominal effusion, anemia, leukocytosis, and thrombocytopenia. Histoplasmosis characteristically is a disease of the mononuclear phagocyte system, but in this(More)
Osseous metaplasia of the pericardium causing effusive-constrictive pericardial disease has not, to our knowledge, been reported in dogs. Clinical signs of right-sided congestive heart failure prompted examination of the dog of this report. Documented causes of constrictive pericardial disease in dogs include trauma and actinomycotic, mycobacterial, and(More)
A 1-yr-old male leopard (Panthera pardus) presented for intermittent anorexia, emaciation, and generalized muscle wasting. Plain radiographs, ultrasonography, and esophageal endoscopy led to a diagnosis of diaphragmatic eventration with probable concurrent hiatal hernia. An exploratory laparotomy confirmed both diagnoses, and surgical repair and(More)
Plastinated specimens, when prepared with a design for endoscopic use, can serve as a practical model for teaching. Intact alimentary canals were excised from fresh canine cadayers. Cannulas in excess of the intended endoscope size (9.6 mm diameter) were placed in restrictive openings [cardiac ostium (ostium cardiacum), pyloric ostium (ostium pyloricum) and(More)
The extraction of the hepatobiliary radiopharmaceutical 99mTc-mebrofenin (Choletec) by the liver can be used to evaluate the severity of hepatocellular disease. The hepatic parenchymal cells extract mebrofenin from the blood by the same active transport mechanism as bilirubin. The ability of the liver to extract 99mTc-mebrofenin is a measure of hepatic(More)