Robert B. Rose

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Rigid body rotation of five domains and movements within their interfacial joints provide a rational context for understanding why HIV protease mutations that arise in drug resistant strains are often spatially removed from the drug or substrate binding sites. Domain motions associated with substrate binding in the retroviral HIV-1 and SIV proteases are(More)
The structure of an early M-intermediate of the wild-type bacteriorhodopsin photocycle formed by actinic illumination at 230 K has been determined by x-ray crystallography to a resolution of 2.0 A. Three-dimensional crystals were trapped by illuminating with actinic light at 230 K, followed by quenching in liquid nitrogen. Amide I, amide II, and other(More)
Immune-mediated diseases are common and life-threatening disorders in dogs. Many canine immune-mediated diseases have strong breed predispositions and are believed to be inherited. However, the genetic mutations that cause these diseases are mostly unknown. As many immune-mediated diseases in humans share polymorphisms among a common set of genes, we(More)
The subtle effects of DNA-protein recognition are illustrated in the homeodomain fold. This is one of several small DNA binding motifs that, in spite of limited DNA binding specificity, adopts crucial, specific roles when incorporated in a transcription factor. The homeodomain is composed of a 3-helix domain and a mobile N-terminal arm. Helix 3 (the(More)
  • W P Allis, Prof J A H Rose, S C Shapiro, Prof J B Brown, Wiesner, C C D Brown +20 others
  • 2009
Foundation and is under the overall supervision of the Plasma Dynamics Committee of Massachusetts Institute of Technology. The general objective is to combine the technical knowledge of several departments, in a broad attempt to understand electrical plasmas, to control them, and to apply them to the needs of communication, propulsion, power conversion, and(More)
of the electron temperature T and of the electron density n column that was heated at one end and immersed in an axial obtained the following differential equation for the variation discussed the spatial decay along the z-axis of a plasma dc magnetic field B. We of T with z: d 2 U dU dz 2 dz 0 subject to the boundary conditions: U = Umax , at z = 0; and(More)
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