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OBJECTIVE To determine if naturally produced speech stimuli evoke distinct neural response patterns that can be reliably recorded in individuals. DESIGN Auditory cortical evoked potentials were obtained from seven normal-hearing young adults in response to four naturally produced speech tokens (/bi/, /pi/, /[U0283]i/, and /si/). Stimuli were tokens from(More)
OBJECTIVE To examine the attitudes, beliefs, and behaviors of parents whose children were underimmunized with respect to > or =2 vaccines that have recently received negative attention, compared with parents whose children were fully immunized with respect to the recommended vaccines. DESIGN Case-control study. SETTING A sample of households that(More)
Serum selenium and vitamin E levels have been measured in subjects with established alcoholic liver disease, in alcoholics within the community, and in appropriate controls. Both serum selenium and vitamin E levels were shown to be significantly depressed (P less than 0.01) in the alcoholic study groups and serum selenium was more markedly depressed in(More)
Telephone surveys are widely used in the U.S.A. for the study of health-related topics. They are subject to 'coverage bias' because they cannot sample households that do not have telephones. Although only around 5 per cent of households do not have a telephone, rates of telephone coverage show substantial variation by geography, demographic factors and(More)
OBJECTIVES To study the impact of injection of verapamil and adenosine in the coronary arteries on TIMI (Thrombolysis in Myocardial Infarction) frame count (TFC) after percutaneous coronary intervention (PCI) in patients with an acute coronary syndrome (ACS). METHODS Prospective, randomised, controlled study of the intracoronary administration of normal(More)
OBJECTIVES We sought to compare emergency coronary angiography with or without rescue percutaneous coronary intervention (PCI) with conservative treatment in patients with failed fibrinolysis complicating ST-segment elevation myocardial infarction (STEMI). BACKGROUND Most patients with STEMI receive fibrinolytic therapy and aspirin. The management of(More)
1. Introduction Nonresponse causes bias in survey results when nonrespondents differ in important ways from respondents. This paper focuses on potential nonresponse bias in surveys that first screen a sample to determine eligibility for the study and then complete an interview with eligible respondents. Nonresponse to the screening interview may be(More)
Decreased albumin synthesis by hepatocytes in liver injury is thought to occur in response to Kupffer cell-derived acute-phase cytokines. In this study we used hepatocytes maintained in a differentiated phenotype, by culture on a laminin-rich gel substratum (Engelbreth-Holm-Swarm matrix), to investigate the effects of Kupffer cell-conditioned medium and(More)
BACKGROUND Effective endogenous fibrinolysis requires rapid release of tissue plasminogen activator (tPA) from the vascular endothelium. Smoking is a known risk factor for arterial thrombosis and myocardial infarction, and it causes endothelial dysfunction. We therefore examined the effects of cigarette smoking on substance P-induced tPA release in vivo in(More)