Robert A Moss

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Advanced glycation end products (AGEs) exert their cellular effects on cells by interacting with specific cellular receptors, the best characterized of which is the receptor for AGE (RAGE). The transductional processes by which RAGE ligation transmits signals to the nuclei of cells is unknown and was investigated. AGE-albumin, a prototypic ligand, activated(More)
We assessed the safety and efficacy of melphalan, arsenic trioxide (ATO) and ascorbic acid (AA) (MAC) combination therapy for patients with multiple myeloma (MM) who failed more than two different prior regimens. Patients received melphalan (0.1 mg/kg p.o.), ATO (0.25 mg/kg i.v.) and AA (1 g i.v) on days 1-4 of week 1, ATO and AA twice weekly during weeks(More)
A variety of drugs and other agents have been reported to cause immune-mediated platelet destruction. The cardinal features of this syndrome are acute, often alarming, purpura, closely related to drug exposure, which remits in one to two weeks after discontinuation of all suspect drugs. Quinidine and quinine have been most commonly implicated but, recently,(More)
Carfilzomib, a proteasome inhibitor, is approved in the United States as a single agent, and in combination with dexamethasone or lenalidomide/dexamethasone (KRd) for relapsed or refractory multiple myeloma (MM). Under the single-agent and KRd approvals, carfilzomib is administered as a 10-minute IV infusion on days 1, 2, 8, 9, 15, and 16 of 28-day cycles(More)
We report the first measured activation parameters for the additions of CCl2 and CClF to simple alkenes and demonstrate the existence of enthalpic barriers for CCl2 additions to cyclohexene and 1-hexene. With these two alkenes, additions of PhCCl are "dominated" by entropic contributions to deltaG++ and additions of CCl2 display comparable contributions of(More)
Six cases of acute thrombocytopenic purpura occurred secondary to heroin abuse. Five of the six affected patients were seen over a six-month period between November 1977 and March 1978, and the last patient was seen in November 1978. The clinical manifestations were characteristic of drug-induced immune thrombocytopenia. We suspect this syndrome is related(More)
Diazirines are prime precursors for carbenes. In this Account, we discuss the synthetic and mechanistic dimensions that govern the range, availability, and utility of diazirines. We focus on the Graham reaction, which affords halodiazirines from amidines in a one-pot procedure, and the diazirine exchange reaction, which allows easy replacement of an initial(More)
Ultrafast photolysis (lambdaex = 270, 350, or 360 nm) of bromophenyl, chlorophenyl, fluorophenyl, and fluoro-para-trifluoromethylphenyl diazirines produces transient species which absorb broadly in the UV and visible regions. Transient decay can be fit to either mono- or biexponential functions (tau1 approximately 0.3-10 ps, tau2 approximately 10-350 ps;(More)
The modification of the psychological deficit in the free and fixed recall performance of low level functioning schizophrenics was examined. One hundred and eighty-seven male and female schizophrenics were divided into three groups according to their level of functioning on their hospital ward and were tested on free and fixed recall tasks under two(More)