Robert A. Moreau

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Patch clamp experiments were performed on two human osteosarcoma cell lines (MG-63 and SaOS-2 cells) that show an osteoblasticlike phenotype to identify and characterize the specific K channels present in these cells. In case of MG-63 cells, in the cell-attached patch configuration (CAP) no channel activity was observed in 2 mM Ca Ringer (control condition)(More)
Increased susceptibility to bacterial and viral infections and dysfunctional erythropoiesis are characteristic of malaria and other hemolytic hemoglobinopathies. High concentrations of free heme are common in these conditions but little is known about the effect of heme on adaptive immunity and erythropoiesis. Herein, we investigated the impact of heme(More)
Sustained erythropoiesis and concurrent bone marrow hyperplasia are proposed to be responsible for low bone mass density (BMD) in chronic hemolytic pathologies. As impaired erythropoiesis is also frequent in these conditions, we hypothesized that free heme may alter marrow and bone physiology in these disorders. Bone status and bone marrow erythropoiesis(More)
In cirrhosis, in splanchnic arteries, endothelium-dependent relaxation may persist even if overactive nitric oxide synthase (NOS) and cyclooxygenase (COX) are inhibited. In normal arteries, a significant endothelium-dependent relaxation to acetylcholine persists after NOS/COX inhibition. This relaxation is caused by smooth muscle cell (SMC) membrane(More)
Scavenger receptor class B type I (SR-BI), the Scarb1 gene product, is a high-density lipoprotein (HDL) receptor which was shown to influence bone metabolism. Its absence in mice is associated with alterations of the glucocorticoid/adrenocorticotropic hormone axis, and translated in high bone mass and enhanced bone formation. Since the cellular alterations(More)
authors are solely responsible for the content of this technical presentation. The technical presentation does not necessarily reflect the official position of the American Society of Agricultural Engineers (ASAE), and its printing and distribution does not constitute an endorsement of views which may be expressed. Technical presentations are not subject to(More)
This study was undertaken to investigate the possibility of using air aspiration to remove fiber from distillers dried grains with solubles (DDGS), produced from fuel ethanol and beverage alcohol cereal grain dry–grind processes. The aspirated fraction was called " aspirated DDGS " and the remaining fraction (original DDGS without the aspirated fraction)(More)
his award address was " Using Sterols to Probe the Structure and Define the Function of Membrane Organization. " Dr. London conducted pioneer research on the identification of " lipid rafts " in biological membranes [3]. Dr. London graciously agreed to provide the review which is the first paper in this volume. The review is followed by four additional(More)
A. Reduce costs of harvesting, handling and transporting biomass to increase the competitiveness of biomass as a feedstock for biofuels, biomaterials and biochemicals. B. Improve biofuel production processes. C. Identify, develop and evaluate sustainable processes to convert biomass resources into biochemicals, biocatalysts and biomaterials. D. Identify and(More)
Bone tissue is continuously remodeled by bone cells and maintenance of its mass relies on the balance between the processes of resorption and formation. We have reported the expression of numerous scavenger receptors, namely scavenger receptor (SR) class B type I and II (SR-BI and SR-BII), and CD36, in bone-forming osteoblasts but their physiological roles(More)
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