Robert A Meck

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AT-125, (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 microM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 gamma-glutamyl transpeptidase (10 nmol/min/10(6) cells) was irreversibly inactivated by AT-125(More)
A human squamous cell carcinoma of the virus was xenografted to athymic, nude mice. A tissue culture cell line designated SqCaVu-1H was derived from a second-passage xenograft. The growth characteristics and cell cycle kinetics in the xenografts and in SqCaVu-1H cells were compared. Approximately 80% of the tumor implants produced growing xenografts which(More)
Scientific data are reviewed to evaluate the risks of radioiodine uptake and to compare those risks with the benefits and risks of low milligram doses of stable potassium iodide (KI). The limit of 25 rad to the thyroid due to radioiodine uptake is adopted as the "break-even" point above which 130-mg KI doses should be administered. The biological and(More)
In order to investigate some characterist ics of Mil l ipore diffusion chamber cultures (DCC) and their potential for the quantitation of tumor cell growth kinetics, HeLa S-3-cells were grown in diffusion chambers implanted i.p. in mice. HeLa cells grew pseudologari thmical ly in DCC with a populat ion-doubl ing time of approximately 2.8 days when 9.2 to(More)
The effects of erythropoietin on the differentiation of murine bone marrow injected into the omenta of x-irradiated mice were investigated. Experimental hosts were injected with 2.5 units of erythropoietin on days 0-7 and sacrificed on day 10. Control hosts were injected with saline or sheep serum. After 10 days the grafts were greater than 95% granulocytic(More)
The time required for the complete decay of a radioactive source can be quantified by specifying an acceptable probability and using an original derivation. The physical phenomenon of complete decay may be used as the technical basis to change regulations and permit, with public acceptance, the inexpensive disposal of short half-lived radioactive waste into(More)
In order to investigate some characteristics of Millipore diffusion chamber cultures (DCC) and their potential for the quantitation of tumor cell growth kinetics, HeLa S-3-cells were grown in diffusion chambers implanted i.p. in mice. HeLa cells grew pseudologarithmically in DCC with a population-doubling time of approximately 2.8 days when 9.2 to 12.0 X(More)