Robert A Honkanen

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PURPOSE To evaluate risk factors for definite open-angle glaucoma (OAG), based on African-descent participants of the Barbados Eye Studies. DESIGN Cohort study with 81% to 85% participation over 9 years' follow-up. PARTICIPANTS We evaluated 3222 persons at risk, 40 to 84 years old, who did not have definite OAG at baseline. METHODS Participants had(More)
PURPOSE To present long-term results of eyes with penetrating keratoplasty (PK) and glaucoma tube implant. DESIGN Retrospective, noncomparative, interventional case series. PARTICIPANTS We retrospectively reviewed medical records of all patients who underwent both PK and glaucoma tube implant (Baerveldt or Ahmed) at the University of Iowa between July(More)
Diseases and medications associated with the occurrence of falls leading to medical treatment in elderly Finns (65 yrs or older) during a one-year period are presented. The design was that of a case-control study involving 380 fallers seeking medical treatment and 342 unmatched controls selected randomly from the population register. The occurrence of a(More)
PURPOSE To evaluate the role of baseline intraocular pressure (b-IOP) as a risk factor for incident open-angle glaucoma (OAG) in participants of African origin from the Barbados Eye Studies. DESIGN Population-based 9-year cohort study. PARTICIPANTS Three thousand two hundred twenty-two persons examined during the study period who were free of glaucoma(More)
The incidence of falling injuries leading to medical treatment was described by sex, age, marital status, education, amount of daily motion, self-perceived health, mechanism of fall and severity of injury. Material was collected regarding persons aged 65 years or over seeking medical treatment due to a fall during a period of one year. Altogether 3.8% of(More)
OBJECTIVE To describe the incidence and associated factors of injury-causing falls by place of residence. DESIGN A prospective population-based study. SETTING Five municipalities in northern Finland. PARTICIPANTS All persons in the five communities aged 70 years or older living at home (n = 1016) and in long-term institutionalized care (n = 143). (More)
Barbiturates reduce cerebral blood flow, metabolism, and Glc transfer across the blood-brain barrier. The effect of barbiturates on hexose transport in cultured mammalian cell lines and human erythrocytes was studied. Pentobarbital inhibits [3H]-2-dGlc uptake in 3T3-C2 murine fibroblasts by approximately 95% and approximately 50% at 10 and 0.5 mM,(More)
Antibody to the carboxyl-terminal of hexose transporter protein GLUT-1 was used to localize this carrier in normal rat kidney (NRK) cells during D-glucose (Glc) deprivation. Glc-deprivation of NRK cells induces increased hexose transport, inhibits the glycosylation of GLUT-1, and increases the content of both native, 55,000 apparent mol wt (Mr) and aglyco,(More)
PURPOSE Mutations of the forkhead transcription factor gene FOXC1 result in anterior segment anomalies. No description of the spectrum of defects resulting from a single point mutation of this gene exists in the ophthalmology literature. We have screened all available patients with Axenfeld-Rieger genes (PITX2 and FOXC1). In this report, we clinically(More)
PURPOSE To determine the 9-year incidence of open-angle glaucoma (OAG) in African-descent participants of the Barbados Eye Studies. DESIGN Nine-year cohort study with 81% to 85% participation. PARTICIPANTS Three thousand two hundred twenty-two persons without definite OAG at baseline, at risk of developing OAG at follow-up. METHODS The standardized(More)