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PD-1, a receptor expressed by T cells, B cells, and monocytes, is a potent regulator of immune responses and a promising therapeutic target. The structure and interactions of human PD-1 are, however, incompletely characterized. We present the solution nuclear magnetic resonance (NMR)-based structure of the human PD-1 extracellular region and detailed(More)
The mechanism by which single-chain urokinase (scuPA) binds to its receptor (uPAR) is incompletely understood. We report that a fragment comprising the first domain of recombinant soluble uPAR (sDI) as well as a fragment comprising the remaining domains (sDII-DIII) competes with the binding of recombinant full-length soluble uPAR (suPAR) to scuPA with an(More)
—We report a theoretical investigation of the crosstalk performance of photonic code-division multiple-access (CDMA) networks that are based on coherent matched filtering of optical pulses. We describe the importance of time gating in the reduction of noise in spread-time CDMA schemes. We give guidelines for the selection of codes in coherent matched(More)
Specific, high affinity protein-protein interactions lie at the heart of many essential biological processes, including the recognition of an apparently limitless range of foreign proteins by natural antibodies, which has been exploited to develop therapeutic antibodies. To mediate biological processes, high affinity protein complexes need to form on(More)
Three aborted canine fetuses were submitted to the Animal Health Diagnostic Center at Cornell University in November 2011 and September 2012 for diagnostic workups to determine the causes of the reproductive difficulties. Histological assessments of the sampled tissues were inconclusive due to the autolysis. Tests to detect bacterial causes of the abortions(More)
Protein:protein interactions are fundamental in living organism homeostasis. Here we introduce VHH6, a junctional epitope antibody capable of specifically recognizing a neo-epitope when two proteins interact, albeit transiently, to form a complex. Orthogonal biophysical techniques have been used to prove the "junctional epitope" nature of VHH6, a camelid(More)
Front c o v e r : Large-bladed c r y s t a l s o f b a r i t e (BaS0,+) surrounded by f i n e-g r a i n e d c r y s t a l s o f p y r i t e (FeS2). Back c o v e r : P y r i t e framboid (F ~ s ~) ; an a g g r e g a t e of c r y s-t a l s t h a t a r e from 1. 5 t o 2 micrometers i n l o n g dimension. Topographic rnapplng in cooperation with the U n i t e d(More)
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