Robert A. Burns

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Discriminant function analysis of data from a double-blind comparative trial of lofepramine (a noradrenaline-specific reuptake inhibitor) and fluoxetine (a serotonin-specific reuptake inhibitor), involving 183 patients was used to identify predictors of response. Psychic anxiety significantly predicted a positive response to antidepressant medication,(More)
BACKGROUND This study was designed to establish whether (as suggested in a number of open and relatively small controlled trials) lithium augmentation is more effective than continued antidepressant alone, where response to a standard course of antidepressant treatment has been absent or partial. METHOD Lithium or placebo was added on a double-blind basis(More)
Shear wave seismic reflection was used to delineate cyclic deposits of massive ice and glacial till in the upper 30 m at a site near Tuktoyaktuk, Northwest Territories, Canada. Shear wave reflections with dominant frequencies in excess of 350 Hz were recorded with a steel shaft and 1 kg hammer source and single 50 Hz horizontal geophones with 30 cm spikes.(More)
Platelet [3H] paroxetine binding was measured in 73 depressed patients and in 64 healthy volunteers. No differences were found in Bmax or Kd either overall, or when the 61 depressed subjects who had never received psychotropic drugs were analysed separately. Within the depressed group, no differences in Bmax or Kd were found between subgroups divided on the(More)
During the last 30 years, we have performed a number of unusual experiments to measure P-and S-wave velocity structure of unconsolidated sediments below the seafloor at sites to water depths of 700 m. These experiments were designed to aid in specific geotechnical problems related to soil stability along pipeline routes or beneath bottom-founded structures(More)
BACKGROUND We examine the effects of cognitive-behavioural therapy (CBT) as an adjuvant to acute physical treatment and lithium maintenance therapy in reducing depression severity over a follow-up year in elderly depressed patients. METHOD The study consists of three phases. During the acute treatment and continuation phase, 17 of 31 patients received CBT(More)
One hundred and eighty three patients with DSM-III-R major depressive illness were allocated randomly to treatment with one of two new generation antidepressants, fluoxetine and lofepramine. Both patient groups had significantly lower mean scores on the Hamilton Depression Rating Scale (HDRS) 6 weeks after entry to the trial (p < 0.001), but there were no(More)
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