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INTRODUCTION The intent of this study was to determine whether serum procalcitonin (PCT) levels are associated with prognosis, measured as organ dysfunctions and 28-day mortality, in patients with severe pneumonia. METHODS This was a multicenter, observational study of critically ill adult patients with pneumonia requiring mechanical ventilation conducted(More)
Chest physical examination often includes performing chest percussion, which involves introducing sound stimulus to the chest wall and detecting an audible change. This approach relies on observations that underlying acoustic transmission, coupling, and resonance patterns can be altered by chest structure changes due to pathologies. More accurate detection(More)
BACKGROUND The response of lung microvascular endothelial cells (ECs) to lipopolysaccharide (LPS) is central to the pathogenesis of lung injury. It is dual in nature, with one facet that is pro-inflammatory and another that is cyto-protective. In previous work, overexpression of the anti-apoptotic Bcl-XL rescued ECs from apoptosis triggered by siRNA(More)
In the present issue of Critical Care, John Marshall and colleagues report on a clinical trial designed to evaluate the use of an EAA in patients admitted to a medical–surgical intensive care unit [1]. Endotoxin plays a central role in sepsis [2,3]. The current 'gold standard' for the determination of endotoxemia is the limulus amebocyte lysate (LAL) assay,(More)
Many pulmonary injuries and pathologies may lead to structural and functional changes in the lungs resulting in measurable sound transmission changes on the chest surface. Additionally, noninvasive imaging of externally driven mechanical wave motion in the chest (e.g., using magnetic resonance elastography) can provide information about lung structural(More)
Severe sepsis and septic shock are among the most common causes of death in noncoronary intensive care units. The incidence of sepsis has been increasing over the past two decades, and is predicted to continue to rise over the next 20 years. While our understanding of the complex pathophysiologic alterations that occur in severe sepsis and septic shock has(More)
Disclosure: Both authors are members of the National Board of Respiratory Care. Neither author has other real or potential conflicts of interest or other disclosures to declare. Introduction Selecting the optimum tidal volume for adult patients on ventilatory support is critical to achieving the best clinical outcomes. Over the years, guidelines about tidal(More)
Endotracheal tubes (ETTs) are used to establish airway access in patients with ventilatory failure and during general anaesthesia. Tube malpositioning can compromise respiratory function and can be associated with increased morbidity and mortality. Clinical assessment of ETT position normally involves chest auscultation, which is highly skill-dependent and(More)
The mechanisms involved in lung cancer (LC) progression are poorly understood making discovery of successful therapies difficult. Adaptor proteins play a crucial role in cancer as they link cell surface receptors to specific intracellular pathways. Intersectin-1s (ITSN-1s) is an important multidomain adaptor protein implicated in the pathophysiology of(More)