Robby Zachariah Tom

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The Rab-GTPase-activating protein TBC1D1 has emerged as a novel candidate involved in metabolic regulation. Our aim was to determine whether TBC1D1 is involved in insulin as well as energy-sensing signals controlling skeletal muscle metabolism. TBC1D1-deficient congenic B6.SJL-Nob1.10 (Nob1.10(SJL)) and wild-type littermates were studied. Glucose and(More)
3 Ferenc Szekeres, Alexandra Chadt, Robby Z. Tom, Atul S. Deshmukh, 4 Alexander V. Chibalin, Marie Björnholm, Hadi Al-Hasani and Juleen R. Zierath 5 6 *These authors have contributed equally to this work. 7 8 9 Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. 10 German Institute of Human Nutrition, Potsdam-Rehbruecke,(More)
Methotrexate (MTX) is a widely used anticancer and antirheumatic drug that has been postulated to protect against metabolic risk factors associated with type 2 diabetes, although the mechanism remains unknown. MTX inhibits 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase (ATIC) and thereby slows the(More)
OBJECTIVE Leptin stimulates peripheral lipid oxidation, but the influence on mitochondrial function is partly unknown. We investigated tissue-specific mitochondrial function in leptin-deficient obese C57BL/6J-ob/ob mice compared to lean littermates following leptin treatment. MATERIALS AND METHODS Lean and obese ob/ob mice were treated with saline or(More)
Skeletal muscle glucose transport is regulated via the canonical insulin-signaling cascade as well as by energy-sensing signals. 5'-AMP-activated protein kinase (AMPK) has been implicated in the energy status regulation of glucose transport. We determined the role of the AMPKgamma3 isoform in hypoxia-mediated energy status signaling and glucose transport in(More)
Leptin regulates food intake and energy expenditure by activating the long form of the leptin receptor (LepRb). Leptin also regulates glucose homeostasis by improving whole-body insulin sensitivity, but the mechanism remains undefined. Leptin action is mediated by phosphorylation of several tyrosine residues on LepRb. LepRb-Tyr985 plays an important role in(More)
Diacylglycerol kinases (DGK) regulate the balance between diacylglycerol (DAG) and phosphatidic acid. DGKζ is highly abundant in skeletal muscle and induces fiber hypertrophy. We hypothesized DGKζ influences functional and metabolic adaptions in skeletal muscle and whole body fuel utilization. DAG content was increased in skeletal muscle and adipose tissue,(More)
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