Rob S. Markel

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Invited Paper Understanding the earth's climate system and how it might be changing is a preeminent scientific challenge. Global climate models are used to simulate past, present, and future climates, and experiments are executed continuously on an array of distributed supercomputers. The resulting data archive, spread over several sites, currently contains(More)
Although functional RNA molecules are known to be biased in overall composition, the effects of background composition on the probability of finding a particular active site by chance has received little attention. The probability of finding a particular motif has important implications both for understanding the distribution of functional RNAs in ancient(More)
A prototype Taskspaces framework for grid computing of scientific computing problems that require intertask communication is presented. The Taskspaces framework is characterized by three major design choices: decentralization provided by an underlying tuple space concept, enhanced direct communication between tasks by means of a communication tuple space(More)
Due to ever-increasing data sizes and the high computational complexity of many algorithms , there is a natural drive towards applying parallel and distributed computing to bioinformatics problems. Grid computing techniques can provide flexible, portable and scalable software solutions for parallel bioinformatics. Here we describe the TaskSpaces software(More)
— In recent years our society has witnessed an unprecedented growth in computing power available to tackle important problems in science, engineering and medicine. For example , the SHARCNET network links large computing resources in 11 leading academic institutions in South Central Ontario, thus providing access to thousands of compute processors. It is a(More)
RNA motifs, also called active sites, consist of a few functional modules separated by unimportant spacer. We have been investigating two well-characterized motifs: The Isoleucine Aptamer The Hammerhead Ribozyme Through a combination of analytical calculations, supercomputer simulations, and laboratory experiments, we find that: 1. Functional RNA motifs may(More)
Researchers across various scientific disciplines seek to develop chemical models for extended and molecular systems. The modeling process revolves around the gradual refinement of assumptions, through comparison of experimental and computational results. One such experimental technique in material science is Solid State Nuclear Magnetic Resonance (NMR), a(More)
A prototype Taskspaces framework for grid computing of scientific computing problems that require intertask communication is presented. The Taskspaces framework is characterized by three major design choices: decentralization provided by an underlying tuple space concept, enhanced direct communication between tasks by means of a communication tuple space(More)
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