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Owing to the prevalence of the JAK2V617F mutation in myeloproliferative neoplasms (MPNs), its constitutive activity, and ability to recapitulate the MPN phenotype in mouse models, JAK2V617F kinase is an attractive therapeutic target. We report the discovery and initial characterization of the orally bioavailable imidazopyridazine, LY2784544, a potent,(More)
A method of extracting extracellularly recorded action potentials from background electronic noise is described. Segments of traces containing stimulus-induced activity are Fourier transformed and the increase in the total power density over that of control noise segments is used as a measure of stimulus-induced neuronal activity. We show first, with(More)
T: The effect of 12-o-binucleated lymphocytes (LWBL): A review of 38 cases. Leuk Lymphoma 20:275, 1996 tetradecanoylphorbol-13-acetate (TPA) on leukemic cells from chronic B-cell leukemias. premature chromosome condensation are recurrent findings in chronic B-cell lymphocytosis with binucleated lymphocytes. Leuk and cytogenetic analysis of hairy cell(More)
This study was conducted to: (1) test the utility of a new and rapid analytical method, pyrolysis molecular beam mass spectrometry (py-MBMS), for the measurement and characterization of carbon in forest soils, and (2) examine the effects of natural disturbance on soil carbon dynamics. An additional objective was to test the ability of py-MBMS to distinguish(More)
PAPERS IN REFEREED JOURNALS T.J. vanderWeele, T.S. Richardson. (2012) General theory for interactions in sufficient cause models with dichotomous exposures. 33 pages. Annals of Statistics. Accepted for publication. Learning high-dimensional directed acyclic graphs with latent and selection variables. Identification of covariates for the non-parametric(More)
In this paper, we investigate the performance of a set based tracker in clutter with no target present. If there is a positive probability of clutter-only tracks lasting an infinite time in such an environment, then a tracker cannot be expected to perform well under these clutter conditions when a target is present. In order to analyze the problem, a(More)
Although the distinction between magnesiodumortieite and dumortierite, i.e. Mg vs. Al dominance at the partially vacant octahedral Al1 site, had met current criteria of the IMA Commission on New Minerals, Nomenclature and Classification (CNMNC) for distinguishing mineral species, the distinction between holtite and dumortierite had not, since Al and Si are(More)
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