Rob I Shulman

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INTRODUCTION A single centre has reported that implementation of an intensive insulin protocol, aiming for tight glycaemic control (blood glucose 4.4 to 6.1 mmol/l), resulted in significant reduction in mortality in longer stay medical and surgical critically ill patients. Our aim was to determine the degree to which tight glycaemic control can be(More)
INTRODUCTION The study aimed to compare the impact of computerised physician order entry (CPOE) without decision support with hand-written prescribing (HWP) on the frequency, type and outcome of medication errors (MEs) in the intensive care unit. METHODS Details of MEs were collected before, and at several time points after, the change from HWP to CPOE.(More)
OBJECTIVES To determine the pharmacokinetic characteristics of linezolid and teicoplanin in critically ill patients. PATIENTS AND METHODS Serum was collected frequently during day 0 and then pre- and 1 h post-dose on days 1, 2, 3, 5, 7 and every third day thereafter during treatment. Serum linezolid concentrations were analysed using HPLC. Serum(More)
BACKGROUND Hemofiltration circuits generally require anticoagulation to prevent the membrane from clotting. Understanding the mechanisms involved in premature clotting of the filtration circuit is useful to optimize anticoagulation and maintain filter patency. AIMS To discuss research performed at our institution which throws light on the causes of(More)
INTRODUCTION Insulin adsorption onto infusion equipment may affect glycaemic control. METHODS The change in insulin concentration during delivery through tubing employed for adult ICU and neonatal patients was determined using continuous flow UV analysis. RESULTS Insulin adsorption depended on tubing composition, dimensions and flow rate, being highest(More)
This review assesses the trial data for low-molecular-weight heparin (LMWH) use in cardiology. LMWHs have been shown to be more convenient to use compared with unfractionated heparin. The use of LMWHs in prevention and treatment of deep vein thrombosis is now established. Use of LMWHs in cardiology is gathering momentum. The most compelling published data(More)
Use of inhaled nitric oxide for treatment of pulmonary hypertension in adult critical illness is limited by its mode of delivery and high costs, prompting evaluation of alternative therapies. We report the use of oral sildenafil in a patient with severe secondary pulmonary hypertension and right ventricular dysfunction. Following reduction in mean pulmonary(More)
PURPOSE Medication-related problems (MRPs) frequently occur at the interfaces of care settings. We examined this further because little has been published about MRPs experienced by patients/carers after discharge from the intensive care unit (ICU). METHODS AND MATERIALS Medication history data were collected before, during, and after ICU admission and by(More)
BACKGROUND Intensive insulin therapy (IIT) has been shown to reduce mortality and morbidity in longer stay, critically ill patients. However, this has been demonstrated in a single site, whereas two multicentric studies have been terminated prematurely mainly due to hypoglycemia. Other difficulties with IIT include efficacy of glycemic control. This report(More)