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BACKGROUND Screening for prostate cancer advances the time of diagnosis (lead time) and detects cancers that would not have been diagnosed in the absence of screening (overdetection). Both consequences have considerable impact on the net benefits of screening. METHODS We developed simulation models based on results of the Rotterdam section of the European(More)
BACKGROUND More than a decade ago, a mammography screening programme for women aged 50-69 years was initiated in the Netherlands. Our aim was to assess the effect of this programme on breast-cancer mortality rates. METHODS We examined data for 27948 women who died of breast-cancer aged 55-74 years between 1980 and 1999 (30560 cases until 2001). We grouped(More)
  • R J M Boer, Ir I S Herschberg, Drs H J J W J Epema, R Heijnsdijk, Van Dantzig
  • 1996
Condor is a distributed batch system for sharing the workload of jobs in a pool of Unix workstations connected by a communication network. An enhancement made to Condor, Condor ocking, enables to connect several Condor pools. The current scheduling algorithm in Condor, matching jobs and idle machines , does not take into account the network communication(More)
OBJECTIVE To determine the incidence of cervical cancer after several negative cervical smear tests at different ages. DESIGN Prospective observational study of incidence of cervical cancer after the third consecutive negative result based on individual level data in a national registry of histopathology and cytopathology (PALGA). SETTING Netherlands,(More)
Dissemination of prostate-specific antigen (PSA) testing in the United States coincided with an increasing incidence of prostate cancer, a shift to earlier stage disease at diagnosis, and decreasing prostate cancer mortality. We compared PSA screening performance with respect to prostate cancer detection in the US population vs in the Rotterdam section of(More)
BACKGROUND Overdiagnosis of clinically insignificant prostate cancer is considered a major potential drawback of prostate-specific antigen (PSA) screening. Quantitative estimates of the magnitude of this problem are, however, lacking. We estimated rates of prostate cancer overdiagnosis due to PSA testing that are consistent with the observed incidence of(More)
BACKGROUND Comprehensive analyses have shown that screening for cancer usually induces net costs. In this study, the possible costs and savings of endoscopic colorectal cancer screening are explored to investigate whether the induced savings may compensate for the costs of screening. METHODS A simulation model for evaluation of colorectal cancer(More)
BACKGROUND Recommended screening policies for cervical cancer differ widely among countries with respect to targeted age range, screening interval, and total number of scheduled screening examinations (i.e., Pap smears). We compared the efficiency of cervical cancer-screening programs by performing a cost-effectiveness analysis of cervical cancer-screening(More)
BACKGROUND The currently recommended frequency for prostate-specific antigen (PSA) screening tests for prostate cancer is 1 year, but the optimal screening interval is not known. Our goal was to determine if a longer interval would compromise the detection of curable prostate cancer. METHODS A cohort of 4491 men aged 55-75 years, all participants in the(More)