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In this work, we aimed at correlating focal atrophy in periventricular structures with cognitive function, in the spectrum from healthy subjects to severe Alzheimer disease: 28 subjects with normal cognition and 84 patients presenting various degrees of cognitive impairment were included in the study. The cognitive level of each subject was assessed with(More)
The aim of this work was to identify ventricular shape-based biomarkers in MR images to discriminate between patients with Alzheimer's disease (AD) and healthy elderly. Clinical MR images were collected for 58 patients and 28 age-matched healthy controls. After normalizing all the images the ventricular cerebrospinal fluid was semiautomatically extracted(More)
Because of its close genetic and physiological similarities to humans, as well as the ease with which its genome can be manipulated, the mouse became the mammalian model of choice for genetic research. A first step in describing the potential impact of a given genetic manipulation is the characterization of general morphology. The use of 3– dimensional(More)
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