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  • Sharon Maor, Doris Y. Mayer, +4 authors Moshe Zvi Papa
  • Biology, Medicine
  • The Journal of endocrinology
  • 2006 (First Published: 1 December 2006)
  • The insulin-like growth factors, IGF-I and IGF-II are a family of mitogenic polypeptides with important roles in growth and differentiation. The biological actions of the IGFs are mediated by theContinue Reading
  • Rive Sarfstein, Yael Friedman, Zohar Attias-Geva, Ami Fishman, Ilan Bruchim, Haim Werner
  • Medicine, Biology
  • PloS one
  • 2013 (First Published: 19 April 2013)
  • Accumulating epidemiological evidence shows that obesity is associated with an increased risk of several types of adult cancers, including endometrial cancer. Chronic hyperinsulinemia, a typicalContinue Reading
  • Rive Sarfstein, Yara Gorzalczany, +6 authors Edgar Pick
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2004 (First Published: 16 April 2004)
  • NADPH oxidase activation involves the assembly of membrane-localized cytochrome b559 with the cytosolic components p47phox, p67phox, and the small GTPase Rac. Assembly is mimicked by a cell-freeContinue Reading
  • Ariel Mizrahi, Yevgeny Berdichevsky, +8 authors Edgar Pick
  • Biology, Medicine
  • Journal of leukocyte biology
  • 2006 (First Published: 1 May 2006)
  • Phagocytes generate superoxide (O2*-) by an enzyme complex known as reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Its catalytic component, responsible for the NADPH-drivenContinue Reading
  • Einat Yehezkel, Doron Weinstein, M. Simon, Rive Sarfstein, Zvi Laron, H. Werner
  • Biology, Medicine
  • Diabetologia
  • 2010 (First Published: 1 December 2010)
  • Aims/hypothesisInsulin analogues were developed to improve the pharmacological properties of injected insulin and to better mimic endogenous insulin output. However, certain insulin analogues haveContinue Reading
  • Naama Reizner, Sharon Maor, +5 authors Haim Werner
  • Biology, Medicine
  • Journal of molecular endocrinology
  • 2005 (First Published: 1 August 2005)
  • The IGF-I receptor (IGF-IR) has an important role in breast cancer development and progression. Previous studies have suggested that the IGF-IR gene is negatively regulated by a number ofContinue Reading