Rittika Shamsuddin

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Effective management of respiratory motion is essential for achieving the clinical goals of stereo tactic thoracic and abdominal radiotherapy, where highly potent radiation beams are precisely directed in order to ablate the tumor, while minimizing radiation damage to normal tissue and critical organs. Due to cycle-to-cycle variations in respiratory motion,(More)
In stereo tactic radiotherapy for thoracic and abdominal tumors, respiratory motion management is crucial for improving efficacy of treatment, while minimizing risk to heathy tissue and organs. Since tumor motion exhibits dynamic variation in characteristics, analyzing the behavior distribution of tumor motion can improve treatment planning. Identifying(More)
A protein's function is determined by the wide range of motions exhibited by its 3D structure. However, current experimental techniques are not able to reliably provide the level of detail required for elucidating the exact mechanisms of protein motion essential for effective drug screening and design. Computational tools are instrumental in the study of(More)
Baseline shifts in respiratory patterns can result in significant spatiotemporal changes in patient anatomy (compared to that captured during simulation), in turn, causing geometric and dosimetric errors in the administration of thoracic and abdominal radiotherapy. We propose predictive modeling of the tumor motion trajectories for predicting a baseline(More)
The joint recognition problem asks for the identification of kinematic joints (e.g., prismatic or revolute) from a geometric constraint system. This problem is motivated by CAD software applications, which allow an engineer to create a design by using intuitive geometric constraints; motion study components built into the software then provide a tool for(More)
Tumor location displacement caused by respiration-induced motion reduces the efficacy of radiation therapy. Three medically relevant patterns are often observed in the respirationinduced motion signal: baseline shift, ES-Range shift, and D-Range shift. In this paper, for patients with lower body cancer, we develop class profiles (a low dimensional pattern(More)
Summary form only given. Both our preliminary works [1], [2], on biomedical sensor signal processing, have focused on abdominal tumor motion traces. In stereotactic radiotherapy for thoracic and abdominal tumors, respiratory motion management is crucial for improving efcacy of treatment, while minimizing risk to heathy tissue and organs. Since tumor motion(More)
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