Learn More
BACKGROUND The Shingles Prevention Study (SPS; Department of Veterans Affairs Cooperative Study 403) demonstrated that zoster vaccine was efficacious through 4 years after vaccination. The Short-Term Persistence Substudy (STPS) was initiated after the SPS to further assess the persistence of vaccine efficacy. METHODS The STPS re-enrolled 7320 vaccine and(More)
BACKGROUND A double-blind, placebo-controlled trial that involved 38,546 subjects > or =60 years old demonstrated efficacy of a high-potency live-attenuated Oka/Merck varicella-zoster virus (VZV) vaccine. The trial included an immunology substudy to determine the relationship of VZV-specific immune responses to vaccination and clinical outcome. METHODS(More)
In holometabolous development, higher insects have two different life forms, the larva and the imago. Both larval and imaginal cells are derived from cells of the blastoderm stage. After the final embryonic wave of mitosis, however, only the imaginal cells remain diploid, proliferate massively and do not differentiate until metamorphosis. The separation of(More)
BACKGROUND After completion of the Shingles Prevention Study (SPS; Department of Veterans Affairs Cooperative Studies Program Number 403), SPS participants who had initially received placebo were offered investigational zoster vaccine without charge. This provided an opportunity to determine the relative safety of zoster vaccine in older adults following(More)
In Drosophila hindgut, Malpighian tubules and posterior midgut develop from the most posterior region of the blastoderm. One of the genes that influences the differentiation of the Malpighian tubules is Krüppel (Kr), a segmentation gene of the gap class. Kr homozygous embryos lack thoracic and abdominal segments and, depending on the allele, develop nearly(More)
Obstruction of the superior vena cava is usually caused by neoplasia; however, benign diseases cause between 3 and 26% of the reported cases (Lokich and Good-man, 1975; Urschel and Paulson, 1966). We describe a superior vena caval syndrome that resolved with chemotherapy for tuberculosis. Case report A 36-year-old man was admitted on 21 January 1976 after(More)
  • 1