Rita Volkinshtein

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Chip-seq experiments are becoming a standard approach for genome-wide profiling protein-DNA interactions, such as detecting transcription factor binding sites, histone modification marks and RNA Polymerase II occupancy. However, when comparing a ChIP sample versus a control sample, such as Input DNA, normalization procedures have to be applied in order to(More)
The proof is based on a very nice recent result of [1]. They defined the following procedure, called SSTP1 in [1], where p j is the p-value for the jth test sequentially tested out of K potential tests, and c ∈ (0, 1) is a fixed threshold: 1. Findˆk = max k ∈ K : 1+#{j≤k:p j >c} #{j≤k:p j ≤c}∨1 ≤ 1−c c q , and setˆk = 0 if the set is empty. 2. Reject all(More)
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