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Restoration of the transcription activation function to mutant p53 in human cancer cells.
The p53 tumor suppressor gene product is a sequence-specific transcription activator frequently mutated in a variety of human malignancies. Typically, tumor-derived p53 missense mutants are defectiveExpand
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The Analysis of H-2 Mutants: Molecular Genetics and Structure/Function Relationships
The class I genes of the murine major histocompatibility complex are located in four regions (K, D, Qa, Tla) along chromosome 17. The K and D regions contain the genes encoding the classical H-2Expand
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