Learn More
ChEMBL is an open large-scale bioactivity database (https://www.ebi.ac.uk/chembl), previously described in the 2012 Nucleic Acids Research Database Issue. Since then, a variety of new data sources and improvements in functionality have contributed to the growth and utility of the resource. In particular, more comprehensive tracking of compounds from(More)
Genome-wide association scans with high-throughput metabolic profiling provide unprecedented insights into how genetic variation influences metabolism and complex disease. Here we report the most comprehensive exploration of genetic loci influencing human metabolism thus far, comprising 7,824 adult individuals from 2 European population studies. We report(More)
The challenge of translating the huge amount of genomic and biochemical data into new drugs is a costly and challenging task. Historically, there has been comparatively little focus on linking the biochemical and chemical worlds. To address this need, we have developed ChEMBL, an online resource of small-molecule SAR (structure-activity relationship) data,(More)
Although individual factors have been shown to predict weight gain, contextual determinants have also attracted attention, with some authors stressing the role played by deprivation, urban sprawl, social capital and safety. Recent evidence has implicated environmental factors that facilitate the consumption of excess calories and/or make it more difficult(More)
Deep grammars handle with precision complex grammatical phenomena and are able to provide a semantic representation of their input sentences in some logic form amenable to computational processing, making such grammars desirable for advanced Natural Language Processing tasks. The robustness of these grammars still has room to be improved. If any of the(More)
This paper centers on some whole-istic organizational and functional aspects of hepatic Schistosoma mansoni granuloma, which is an extremely complex system. First, it structurally develops a collagenic topology, originated bidirectionally from an inward and outward assembly of growth units. Inward growth appears to be originated from myofibroblasts derived(More)
An investigation was conducted to study the robustness of the results obtained from the cellular automata model which describes the spread of the HIV infection within lymphoid tissues [1]. The analysis focussed on the dynamic behavior of the model when defined in lattices with different symmetries and dimensionalities. The results illustrated that the(More)
BACKGROUND The large increase in the number of scientific publications has fuelled a need for semi- and fully automated text mining approaches in order to assist in the triage process, both for individual scientists and also for larger-scale data extraction and curation into public databases. Here, we introduce a document classifier, which is able to(More)
Abstract This paper presents CINTIL-QATreebank, a treebank composed of Portuguese sentences that can be used to support the development of Question Answering systems. To create this treebank, we use declarative sentences from the pre-existing CINTIL-Treebank and manually transform their syntactic structure into a non-declarative sentence. Our corpus(More)