Rita Lavoie

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Histone deacetylase inhibitors (HDACs) have emerged as a novel class of antiproliferative agents. Utilizing structure-based design, the synthesis of a series of sulfonamide hydroxamic acids is described. Further optimization of this series by substitution of the terminal aromatic ring yielded HDAC inhibitors with good in vitro and in vivo activities.
According to the World Health Organization more than half of people on the planet live in urban areas with the expectation that urbanization will continue to expand. It is critical to the health of the environment that this urbanization be appropriately managed. It can be managed by environmental advocates, legislatures, world leaders and others. But(More)
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