Rita Jacoby

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Squamous carcinomas are the most common cause of humoral hypercalcemia of malignancy (HHM) in humans. To develop an animal model of this syndrome, CD-1 female mice were painted with dimethylbenzanthracene, which produced cutaneous squamous carcinomas in the majority of those painted. Greater than 90% of tumor-bearing mice developed a syndrome of(More)
The biological activities of pancreatic presecretory and secretory proteins synthesized in vitro were compared in studies of (a) the binding of nascent amylase to its substrate, glycogen, (b) the binding of nascent trypsinogen 1, trypsinogen 2+3, and chymotrypsinogen 1 to Sepharose-bound soybean trypsin inhibitor, and (c) the activation of nascent(More)
Members of 192 families in the Tel Aviv area were given a battery of eight cognitive tests focusing on spatial measures but sampling verbal, numerical, and perceptual speed domains as well. The patterns of parent-child and sibling correlations gave very weak evidence, if any, for the operation of the X-linked recessive gene postulated by Stafford and others(More)
The mechanism by which secretory proteins are segregated within the cisternal space of microsomal vesicles was studied using dog pancreas mRNA which directs the synthesis of 14 well-characterized nonglycosylated pancreatic exocrine proteins. In the absence of microsomal membranes, each of the proteins was synthesized as larger polypeptide chains(More)
A number of N-substituted ethyl 3-(n- or p-hydroxyphenyl)nipecotates were synthesized to evaluate the role of a m- or p-hydroxy substituted beta-phenethylamine moiety in narcotic antagonist action. Ethyl m- or p-methoxy-phenylcyanoacetate was alkylated with 1-bromo-3-chloropropane. The resultant chloronitriles were hydrogenated (Raney Ni) to amines and(More)
Ever since the work of Charles Darwin, there has been scientific inquiry into the nonverbal expression of emotion. Especially in the past 25 years, evidence for specific constellations of emotional signals has been accumulating. Whereas patterns of facial expression of many basic emotions have been well established, there is insufficient objective research(More)