• Publications
  • Influence
STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease
  • P. Kurup, J. Xu, +4 authors A. Nairn
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 12 January 2015
Significance In neurons, STEP61 (striatal-enriched protein tyrosine phosphatase) protein levels are tightly regulated, and the protein’s up-regulation is implicated in several neuropsychiatricExpand
  • 35
  • 4
  • PDF
GPER activation is effective in protecting against inflammation-induced nigral dopaminergic loss and motor function impairment
Increasing evidence suggest that excessive inflammatory responses from overactivated microglia play a critical role in Parkinson's disease (PD), contributing to, or exacerbating, nigral dopaminergicExpand
  • 23
  • 1
GPER: A new tool to protect dopaminergic neurons?
Parkinson's disease (PD) is characterized by a selective degeneration of nigrostriatal dopaminergic pathway. Epidemiological studies revealed a male predominance of the disease that has beenExpand
  • 22
  • 1
Role of striatal-enriched protein tyrosine phosphatase STEP in the nigrostriatal pathway
ii iii " Alea jacta est " Júlio César iv v AKNOWLEDGEMENTS ix x ABSTRACT Protein tyrosine phosphorylation plays a central role in numerous neuronal processes. It has been implicated in axonal growth,Expand