Rishikesh V. Antre

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Strategies for CADD vary depending on the extent of structural and other information available regarding the target (enzyme/receptor) and the ligands. Computer-aided drug design (CADD) is an exciting and diverse discipline where various aspects of applied and basic research merge and stimulate each other. In the early stage of a drug discovery process,(More)
A QSAR study was performed on a series of substituted pyrazolone derivatives. The compounds in the selected series were characterized by spatial, molecular and electrotopological descriptors using QSAR module of molecular design suite (V-Life MDS 4.0). In present research paper we reported 2D-QSAR studies of substituted pyrazolone derivatives. Correlations(More)
Diabetes mellitus is one of the world’s major diseases. It currently affects an estimated143 million people worldwide and the number is growing rapidly. In the India, about 1-5% population suffer from diabetes or related complication. So there is need to cure this disease. Anti-diabetic drugs treat diabetes mellitus by lowering glucose levels in the blood.(More)
In the present research work, the motto was to develop new chemical entities as potential anti-inflammatory, analgesic and antipyretic agents. Various 4-(2-amino-6-(substituted)pyrimidin-4-yl)-3-methyl-1-(substituted)-1H-pyrazol-5(4H)-one derivatives (5a-5j) and their Schiff bases (6a-6j) were synthesized. The newly synthesized compounds were characterized(More)
Molecular modeling is a general term which covers a wide range of molecular graphics and computational chemistry techniques used to build, display, manipulate, simulate, and analyze molecular structures, and to calculate properties of these structures. Atrovastatin is the active ingredient in the most popular prescription medicine in the world and a member(More)
In present article the anticonvulsant activity of Cuscuta reflexa Roxb. was studied. Which contain flavonoids, glycosides, steroids, alkaloids, cuscutalin, cuscutin, and amarvelin as revealed by phytochemical screening and the main active chemical constituent flavonoid which responsible for depressant activity. It also investigated by studying the effects(More)
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