Rishikesh Mankidy

Learn More
BACKGROUND Plasmalogens, which are key structural phospholipids in brain membranes, are decreased in the brain and serum of patients with Alzheimer disease (AD). We performed this pilot study to evaluate the relation between the levels of circulating plasmalogens and Alzheimer Disease Assessment Scale-Cognitive (ADAS-Cog) scores in patients with AD. (More)
BACKGROUND Disrupted cholesterol regulation leading to increased circulating and membrane cholesterol levels is implicated in many age-related chronic diseases such as cardiovascular disease (CVD), Alzheimer's disease (AD), and cancer. In vitro and ex vivo cellular plasmalogen deficiency models have been shown to exhibit impaired intra- and extra-cellular(More)
High-level induction of fetal (␥) globin gene expression for therapy of ␤-hemo-globinopathies likely requires local chro-matin modification and dissociation of repressor complexes for ␥-globin promoter activation. A novel ␥-globin– inducing short-chain fatty acid derivative (SCFAD), RB7, which was identified through computational modeling, produced a 6-fold(More)
  • 1