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A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.
We define the activity and mechanisms of action of a small molecule lead compound for cancer targeting. We show that the compound, BMH-21, has wide and potent antitumorigenic activity across NCI60… Expand
Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart Failure
Background—Trimethylamine N-oxide (TMAO), a gut microbe–dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having… Expand
Abstract 19028: The Novel H2S Pro-Drug, SG-1002, Preserves Coronary Artery Vascular Reactivity in the Setting of Critical Limb Ischemia in Swine
Introduction: Peripheral artery disease (PAD) including critical limb ischemia (CLI) leads to increased risk of myocardial infarction even in the absence of coronary artery disease (CAD). It has be...
059Renal Sympathetic Denervation Reverses Diastolic Dysfunction in a Rodent Model of Heart Failure with Preserved Ejection Fraction (HFpEF)
071Cardiosphere-Derived Cells Combined with Renal Sympathetic Denervation Improves Ventricular Function and Remodeling Following Ischemic Injury
072A Novel Hydrogen Sulfide Donor, JK1, Protects the Heart Against Pressure Overload Induced Heart Failure A Novel Hydrogen Sulfide Donor, JK1, Protects the Heart Against Pressure Overload Induced…
A hydrogen sulfide prodrug augments angiogenesis in a swine model of critical limb ischemia via a nitric oxide dependent mechanism
A Hydrogen Sulfide Prodrug Augments Angiogenesis in a Swine Model of Critical Limb Ischemia via a Nitric Oxide Dependent Mechanism Amanda M. Rushing, Amy L. Scarborough, Sarah F. Boisvert, Erminia… Expand
Abstract 15178: A Neprilysin Inhibitor, Sacubitril, Fails to Improve Ventricular Contractility and Worsens Vascular Function in Heart Failure
- David J. Polhemus, Rishi K. Trivedi, Z. Li, Hiroshi Koiwaya, Craig Zibilich, D. Lefer
- 14 November 2017
Introduction: Neprilysin is an endopeptidase that degrades various peptides that regulate cardiovascular function such as the natriuretic peptides (NPs), bradykinin, and angiotensin II (Ang II).… Expand
Abstract 16784: Under-Enrollment of Real-World Heart Failure With Preserved Ejection Fraction Patients in Major HFpEF Clinical Trials
Abstract 364: Pathological Effects of Trimethylamine N-oxide (TMAO) on Pressure Overload-induced Heart Failure
Rationale: Trimethylamine N-oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine, is elevated in the circulation of patients at increased risk for heart attack and… Expand