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We define the activity and mechanisms of action of a small molecule lead compound for cancer targeting. We show that the compound, BMH-21, has wide and potent antitumorigenic activity across NCI60… (More)
BACKGROUND Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having… (More)
The epigenetic remodeling of chromatin histone proteins by acetylation has been the subject of recent investigations searching for biomarkers indicative of late onset cognitive loss. Histone… (More)
Introduction: Peripheral artery disease (PAD) including critical limb ischemia (CLI) leads to increased risk of myocardial infarction even in the absence of coronary artery disease (CAD). It has be...
A Hydrogen Sulfide Prodrug Augments Angiogenesis in a Swine Model of Critical Limb Ischemia via a Nitric Oxide Dependent Mechanism Amanda M. Rushing, Amy L. Scarborough, Sarah F. Boisvert, Erminia… (More)
Introduction: Neprilysin is an endopeptidase that degrades various peptides that regulate cardiovascular function such as the natriuretic peptides (NPs), bradykinin, and angiotensin II (Ang II).… (More)
Rationale: Trimethylamine N-oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine, is elevated in the circulation of patients at increased risk for heart attack and… (More)