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A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.
We define the activity and mechanisms of action of a small molecule lead compound for cancer targeting. We show that the compound, BMH-21, has wide and potent antitumorigenic activity across NCI60Expand
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Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart Failure
Background—Trimethylamine N-oxide (TMAO), a gut microbe–dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients havingExpand
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Abstract 19028: The Novel H2S Pro-Drug, SG-1002, Preserves Coronary Artery Vascular Reactivity in the Setting of Critical Limb Ischemia in Swine
Introduction: Peripheral artery disease (PAD) including critical limb ischemia (CLI) leads to increased risk of myocardial infarction even in the absence of coronary artery disease (CAD). It has be...
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A hydrogen sulfide prodrug augments angiogenesis in a swine model of critical limb ischemia via a nitric oxide dependent mechanism
A Hydrogen Sulfide Prodrug Augments Angiogenesis in a Swine Model of Critical Limb Ischemia via a Nitric Oxide Dependent Mechanism Amanda M. Rushing, Amy L. Scarborough, Sarah F. Boisvert, ErminiaExpand
Abstract 15178: A Neprilysin Inhibitor, Sacubitril, Fails to Improve Ventricular Contractility and Worsens Vascular Function in Heart Failure
Introduction: Neprilysin is an endopeptidase that degrades various peptides that regulate cardiovascular function such as the natriuretic peptides (NPs), bradykinin, and angiotensin II (Ang II).Expand
Abstract 364: Pathological Effects of Trimethylamine N-oxide (TMAO) on Pressure Overload-induced Heart Failure
Rationale: Trimethylamine N-oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine, is elevated in the circulation of patients at increased risk for heart attack andExpand