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Pediatric CLIF-SOFA score is the best predictor of 28-day mortality in children with decompensated chronic liver disease.
BACKGROUND & AIMS Early identification of children with decompensated chronic liver disease (DCLD) at risk of short-term mortality helps improve outcome. We aimed to evaluate the predictors ofExpand
Autoimmune Pancreatitis and IgG4 Related Disease in Three Children
3 children who presented with fever and abdominal pain, deranged liver function tests, and on abdominal ultrasound were found to have an enlarged pancreas, substantial abdominal lymphadenopathy, and extrahepatic biliary duct dilatation associated with autoimmune pancreatitis. Expand
Prevalence, Clinical Profile, and Outcome of Ascitic Fluid Infection in Children With Liver Disease
Half of children with liver disease-related ascites have SBP/CNNA; 50% are symptomatic for AFI, and patients with CLD with SBP /CNNA have a mortality of 24% over 1year follow-up, similar to CNNA. Expand
Outpatient Liver Biopsy in Children: Safety, Feasibility, and Economic Impact.
The present study suggests that if an observation period of 8 hours is instituted, outpatient liver biopsies can be performed safely in children, and that performing liver biopsy on an outpatient basis would have saved 60 beds/AU$ 80,000/year. Expand
Prevalence, Natural History, and Outcome of Acute Fluid Collection and Pseudocyst in Children With Acute Pancreatitis
Only patients with symptomatic pseudocyst need drainage, and asymptomatic pseudocryst can be safely observed irrespective of size and duration of collection, according to this evaluation of children with acute pancreatitis. Expand
Role of Procalcitonin and C-Reactive Protein As Biomarkers of Infection in Children With Liver Disease
PCT and CRP are reliable markers of infection and correlate with infection severity in children with liver disease and their diagnostic accuracy is better in DCLD than ALF cases. Expand
Prevalence and Impact of Bacterial Infections in Children With Liver Disease-A Prospective Study.
Infections develop in 40% ALF and 57% DCLD children and most culture isolates are resistant to cephalosporins and fluoroquinolones and 23% have MRB. Expand
Impact of Changing Treatment Strategies on Outcomes in Pediatric Ulcerative Colitis.
A reduction in 2-year colectomy rates has been observed in patients with pediatric ulcerative colitis since biologics have become available for its treatment and the use of infliximab OR 3.7 was independently associated with it. Expand
Lower 6-MMP/6-TG Ratio May Be a Therapeutic Target in Pediatric Autoimmune Hepatitis
Thiopurine metabolite levels should be measured in patients with AIH who have experienced a loss of remission, and a 6-MMP/6-TG ratio of <4 with the addition of allopurinol could be considered in these patients. Expand
Normal Gamma Glutamyl Transferase Levels at Presentation Predict Poor Outcome in Biliary Atresia.
Outcomes of a single-centre Australian cohort of infants with biliary atresia were described and the impact of GGT level at presentation on outcomes on outcomes in BA was assessed to find low GGT levels at presentation in biliaryatresia was associated with a poorer outcome. Expand