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The iPlant Collaborative (iPlant) is a United States National Science Foundation (NSF) funded project that aims to create an innovative, comprehensive, and foundational cyberinfrastructure in support of plant biology research (PSCIC, 2006). iPlant is developing cyberinfrastructure that uniquely enables scientists throughout the diverse fields that comprise(More)
The Computational Chemistry Grid (CCG) is a 3-year, National Middleware Initiative (NMI) program to develop cyberinfrastructure for the chemistry community. CCG is led bypercomputing Applications. In this paper we discuss our experience developing the CCG cyber-infrastructure in the first year of the project. We pay special attention to sociological as well(More)
—The iPlant Foundation API (fAPI) is a hosted, Software-as-a-Service (SaaS) resource for the computational biology field. Unlike many other grid-based approaches to distributed infrastructure, the fAPI provides a holistic view of core computing concepts such as security, data, applications, jobs, and systems. It also provides the support services, such as(More)
Neutrophils contribute to the pathophysiology of various ischaemic states. Since many agents thought to be antiplatelet have also been shown to affect neutrophil function, it was of interest to examine the effect of ticlopidine (250 mg, p.o., b.i.d. for three doses), an antiplatelet agent, on fMLP (formyl-methionyl-leucyl-phenylalanine) stimulated(More)
Transforming growth factor-beta 1 (TGF-beta 1), suggested in some studies to suppress astrocyte and neutrophil function, has also reduced ischaemic brain injury when administered immediately prior to clot embolization in models of thromboembolic stroke. The effect of TGF-beta 1 as a post-treatment paradigm was investigated in a rabbit model of(More)
This paper describes the WeFold gateway that provides a social and technical environment for the first large-scale attempt at collaboration within the context of the Critical Assessment of techniques for protein Structure Prediction (CASP) competition. CASP is a biennial worldwide experiment created 20 years ago to advance the field of protein folding, one(More)
The NSF TeraGrid project has designed and constructed a federated integrated information service (IIS) to serve its capability publishing and discovery needs. This service has also proven helpful in automating TeraGrid's operational activities. We describe the requirements that motivated this work; IIS's system architecture, information architecture, and(More)