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New thermolytic carbamoyl groups for the protection of nucleobases.
- A. Ohkubo, Rintaro Kasuya, K. Miyata, H. Tsunoda, K. Seio, M. Sekine
- ChemistryOrganic & biomolecular chemistry
- 4 February 2009
It was found that N-arylcarbamoyl and N-(phenylsulfonyl)carbamoyl (psc) groups could be effectively introduced onto the amino groups of deoxycytidine and deoxyadenosine derivatives and could be…
Efficient synthesis of functionalized oligodeoxyribonucleotides with base-labile groups using a new silyl linker.
‘Protected DNA Probes’ capable of strong hybridization without removal of base protecting groups
Several successful applications of this PDP strategy to single nucleotide polymorphism detection are described in detail using PDPs immobilized on glass plates and those prepared on CPG plates, suggesting its potential usefulness.
Development of a new method for the synthesis of oligodeoxynucleotides by use of carbamoyl-type protecting groups.
- A. Ohkubo, Rintaro Kasuya, K. Miyata, H. Taguchi, K. Seio, M. Sekine
- ChemistryNucleic acids symposium series
- 1 November 2007
The phenylsulfonylcarbamoyl group was found to be rapidly removed from three kinds of nucleobases, cytosine, adenine, and guanine bases and the synthesis of oligodeoxynucleotides could be carried out by using the thermolytic protecting group for base protection.
SNPs analysis by use of protected oligonucleotide probes.
- A. Ohkubo, Rintaro Kasuya, Kazushi Sakamoto, H. Taguchi, K. Seio, M. Sekine
- Biology, ChemistryNucleic acids symposium series
- 1 September 2005
The protected oligonucleotide probes containing dC(ac) and d[oxoA(ac)] instead of dC and dA proved to have similar affinity for ssDNA having the complementary sequence and base recognition ability compared with the corresponding unmodified DNA probes.