Rima Shimono

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Differences in the uptake of tracers from radioactive 2-deoxyglucose ([1,2-3H] and [2,6-3H]), and glucose ([1-3H], [3-3H]) into hippocampal regions were investigated by freeze-mount microautoradiography after 45 min for 2-deoxyglucose, and after 15 and 45 min for glucose. Silver grains were assessed quantitatively by an image analyser. (1) The radioactivity(More)
The distribution of 35S-taurine in rat neonates and adults was investigated by wholy-body autoradiography. The neonates (4-day-old) were frozen in dry-ice hexane at 30 min, 1, 3 and 6 h after an intraperitoneal injection of 35S-taurine, whereas survival intervals for adult rats were 1 and 3 h. Whole-sagittal sections of the frozen rat, obtained by using a(More)
The distribution of the glucose-6-phosphatase (G6Pase) activities was demonstrated by in vitro whole-body autoradiography. Relatively high activities were observed in the liver, kidney, and small intestine of mice. However, these organs did not exhibit uniform activity throughout. The activity of the liver was found heterogeneous, but that of the duodenum(More)
Multiple-dose ophthalmic preparations that do not contain preservatives carry high risks of microbial contamination. However, there are various types of hospital preparations, with different physicochemical properties. In the present study, we evaluated the association between physicochemical properties and microbial contamination in ophthalmic(More)
The distribution and fate of 35S from [35S]-cysteine and 14C from [1-14C]-cystine, both precursors to taurine in 17-day pregnant mice and (1-day-old) neonates were investigated by whole-body autoradiography following IV injection for the pregnant mice and IP injection for the neonates. Survival intervals were 30 min, 3 hr. In the dam, 35S and 14C were both(More)
BACKGROUND Obese persons have a higher incidence of depression than healthy-weight persons. Several studies indicated that the exposure to a high fat diet (HFD) results in a decrease in hippocampal neurogenesis, which leads to higher stress response and stress-induced depression. Although stress is a risk factor for obesity and depression, no studies to(More)