Rikki A. M. Brown

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THERE iS considerable evidence that the progressive growth of solid tumours is dependent on their ability to induce the growth of new blood vessels from their Original work by Folkman et al. (1971) indicated that such neovascularization was induced by a humoral mediator secreted by the tumour, which they called tumour angiogenesis factor (TAF). They(More)
BACKGROUND Ovarian cancer is the most lethal gynaecological cancer. Progression-free and overall survival is significantly related to surgical success and residual disease volume. It is unclear whether this survival advantage is due to an intrinsic biological element of the tumour cells which enables successful surgery and improved prognosis, or(More)
One hundred and forty-eight patients with Hodgkin's disease (HD) were stratified into 4 groups according to atopic status. Group 1 had a personal history of atopy and Group 2 a family history of atopy. In Groups 3 and 4 there was no history of atopy but high serum IgE levels (Group 3) and normal IgE levels (Group 4). Comparison of the survival of these(More)
microRNAs (miRNAs) are a family of short, non-coding RNA molecules that drive a complex network of post-transcriptional gene regulation by enhancing target mRNA decay and/or inhibiting protein synthesis from mRNA transcripts. They regulate genes involved in key aspects of normal cell growth, development and the maintenance of body homeostasis and have been(More)
A low-mol.-wt compound isolated from rat Walker 256 carcinoma and found to induce neovascularization in vivo was tested on cultures of cow brain-derived endothelial cells (CBEC) growing on plastic and collagen substrates. This factor had a mitogenic effect on CBEC cultured on native collagen gels and for this reason has been called(More)
Treatment of abdominal lymphoma can be associated with bowel stricture or perforation. Rarely, the common bile duct or portal vein can be involved. This is the first case of stricture formation of both the portal vein and common bile duct in a patient following successful treatment of lymphoma. The development of extensive hilar varices rendered surgical(More)
The serum substance (Ss) and sex-linked protein (Slp) molecules are mouse plasma proteins that exhibit genetic variations controlled by the S region of the Ho2 gene complex (1). The function of these proteins remained unknown for over a decade until 1973 when Demant et al. (2) showed that total hemolytic complement levels were linked to H-2 and that(More)
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