Rikkert Hindriks

Learn More
During the last several years, the focus of research on resting-state functional magnetic resonance imaging (fMRI) has shifted from the analysis of functional connectivity averaged over the duration of scanning sessions to the analysis of changes of functional connectivity within sessions. Although several studies have reported the presence of dynamic(More)
The default mode network (DMN) is a commonly observed resting-state network (RSN) that includes medial temporal, parietal, and prefrontal regions involved in episodic memory [1-3]. The behavioral relevance of endogenous DMN activity remains elusive, despite an emerging literature correlating resting fMRI fluctuations with memory performance [4,(More)
OBJECTIVES Generalized periodic discharges (GPDs) can be observed in the electroencephalogram (EEG) of patients after acute cerebral ischemia and reflect pathological neuronal synchronization. Whether GPDs represent ictal activity, which can be treated with anti-epileptic drugs, or severe ischemic damage, in which treatment is futile, is unknown. We(More)
The most salient feature of spontaneous human brain activity as recorded with electroencephalography (EEG) are rhythmic fluctuations around 10Hz. These alpha oscillations have been reported to propagate over the scalp with velocities in the range of 5-15m/s. Since these velocities are in the range of action potential velocities through cortico-cortical(More)
a Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain b Department of Health Sciences and Technology, ETH Zurich, Switzerland c Department of Experimental Psychology, University of Oxford, United Kingdom d Department of Physiology of Cognitive(More)
The EEG of patients in non-convulsive status epilepticus (NCSE) often displays delta oscillations or generalized spike-wave discharges. In some patients, these delta oscillations coexist with intermittent epileptic spikes. In this study we verify the prediction of a computational model of the thalamo-cortical system that these spikes are phase-locked to the(More)
Multi-electrode recordings of local field potentials (LFPs) provide the opportunity to investigate the spatiotemporal organization of neural activity on the scale of several millimeters. In particular, the phases of oscillatory LFPs allow studying the coordination of neural oscillations in time and space and to tie it to cognitive processing. Given the(More)
During the maintenance period of propofol-induced general anesthesia, specific changes in spontaneous EEG rhythms can be observed. These comprise increased delta and theta power and the emergence of alpha oscillations over frontal regions. In this study we use a meanfield model of the thalamo-cortical system to reproduce these changes and to elucidate the(More)
Although a large number of studies have been devoted to establishing correlations between changes in amplitude and frequency of EEG alpha oscillations and cognitive processes, it is currently unclear through which physiological mechanisms such changes are brought about. In this study we use a biophysical model of EEG generation to gain a fundamental(More)
The functional architecture of spontaneous BOLD fluctuations has been characterized in detail by numerous studies, demonstrating its potential relevance as a biomarker. However, the systematic investigation of its consistency is still in its infancy. Here, we analyze within- and between-subject variability and test-retest reliability of resting-state(More)