Inversion of axial coordination in myoglobin to create a "proximal" ligand binding pocket.Tadayuki Uno, Rikiharu Sakamoto, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Anthony James WilkinsonBiochemistry2003A ligand binding pocket has been created on the proximal side of the heme in porcine myoglobin by site-directed mutagenesis. Our starting point was the H64V/V68H double mutant which has been shown to… (More)