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Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.
In many higher organisms, 5%-15% of histone H2A is ubiquitylated at lysine 119 (uH2A). The function of this modification and the factors involved in its establishment, however, are unknown. Here weExpand
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Expansion of functional human mucosal-associated invariant T cells via reprogramming to pluripotency and redifferentiation.
Mucosal-associated invariant T (MAIT) cells play an important physiological role in host pathogen defense and may also be involved in inflammatory disorders and multiple sclerosis. The rarity andExpand
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A Novel Mouse Model for Invariant NKT Cell Study1
We have generated a novel mouse model harboring the in-frame rearranged TCRVα specific for invariant NKT (iNKT) cells (Vα14-Jα18) on one allele by crossing the mouse cloned from NKT cells withExpand
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Constitutively active Stat5A and Stat5B promote adipogenesis
ObjectiveThe metabolic syndrome is an important social problem affecting many people in developed countries. Obesity is a leading cause of this syndrome, hence understanding molecular mechanismsExpand
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The dynamics of mucosal-associated invariant T cells in multiple sclerosis
BackgroundMultiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelination, gliosis and axonal loss in the Central Nervous System. Although the etiology of the disease hasExpand
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Mucosal-Associated Invariant T Cell Is a Potential Marker to Distinguish Fibromyalgia Syndrome from Arthritis
Background Fibromyalgia (FM) is defined as a widely distributed pain. While many rheumatologists and pain physicians have considered it to be a pain disorder, psychiatry, psychology, and generalExpand
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In vitro induction of natural killer T cells from embryonic stem cells prepared using somatic cell nuclear transfer
The ectopic expression of the Notch receptor ligand delta‐like 1 on stromal cells allows the induction of T cells from embryonic stem cells (ESCs). However, these in vitro‐generated T cells are notExpand
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Mucosal-Associated Invariant T Cells in Regenerative Medicine
Although antibiotics to inhibit bacterial growth and small compounds to interfere with the productive life cycle of human immunodeficiency virus (HIV) have successfully been used to control HIVExpand
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Data-Driven Identification of Adverse Event Reporting Patterns for Japan in VigiBase, the WHO Global Database of Individual Case Safety Reports
Adverse event reporting patterns vary between countries, reflecting differences in reporting culture, clinical practice and underlying patient populations. Japan collects about 60,000 domesticExpand
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Roles of Shc Signaling in Oxidative Stress Response and Aging
The oxidative stress theory of aging has become increasingly accepted as explaining at least in part the aging process. In mammalian genetic models of aging, a genetic deficiency of the p66-shc gene,Expand
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