Rika Kawasaki

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The Sokal and Hasford scores were developed in the chemotherapy and interferon era and are widely used as prognostic indicators in patients with chronic myeloid leukemia (CML). Recently, a new European Treatment and Outcome Study (EUTOS) scoring system was developed. We performed a multicenter retrospective study to validate the effectiveness of each of the(More)
The levels of serum beta-2 microglobulin (β2MG) are determined mainly from lymphoid tissue. To examine its prognostic value in Hodgkin lymphoma (HL), we conducted a retrospective analysis. We analyzed 67 patients with HL diagnosed and treated at seven institutes of the Yokohama City University Hematology Group between 1998 and 2011. The patients included 40(More)
The prognostic implications of infra-diaphragmatic (InD) versus supra-diaphragmatic (SpD) primary lesions in limited-stage diffuse large B-cell lymphoma (DLBCL) remains unknown. This retrospective study aimed to assess the prognostic impact of spD and InD lesions as well as presence of gastrointestinal (GI) involvements in adults with limited-stage DLBCL.(More)
We previously developed a prognostic index, SIL, which includes advanced stage (S), soluble interleukin-2 receptor level (I), and elevated lactate dehydrogenase level (L) in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, hydroxydaunomycin, oncovin, and prednisone (R-CHOP). This time we evaluated the index in a(More)
1. The breathing rhythm-generation mechanism was studied throughout the entire body of the adult lamperey, Entosphenus japonicus, with the body fixed by a specially-designed holder. 2. After brain-stem transection, the rostral part (pontine area) and the caudal part of the medulla (Fig. 2) were found not essential for the generation of respiratory rhythm:(More)
To examine the breathing rhythm-generating mechanism, effects of brain sectioning, immobilization, and electric stimulation on medullary respiratory activities were investigated in adult lampreys. The rostral part of the medulla (rostrally to the level of the caudal border of "internal acoustic pore") is not indispensable for breathing rhythm-generation.(More)
1. The effect of medullary stimulation on breathing movement was studied in the adult lamprey, Entosphenus japonicus. 2. A single, as well as low frequency (less than 5 Hz) pulses applied extracellularly to the medial part of the medulla (as shown in Fig. 1) produced one-to-one movement (contraction followed by relaxation) of branchial baskets, which are(More)
1) Vascular perfusion of the isolated head of the carp was carried out with physiological saline. Respiratory movement of the grill covers and respiratory discharges of cranial motor nerves were recorded in the preparation. 2) Blood vascular vessels supply the brain were anatomically investigated. Concentrations (electrolytes, O2, CO2, and glucose) and(More)
Irradiation therapy alone is a standard strategy for limited-stage FL, leading to a 10-year progression-free survival (PFS) rate of 30-50%. However, we have been administering R-CHOP therapy alone to patients with limited-stage FL. A total of 35 patients with newly diagnosed FL received R-CHOP therapy with curative intent between 2002 and 2009. The median(More)
Dear Editor, Soluble interleukin-2 receptor (sIL-2R) is a widely used in vitro diagnostics for lymphoma. Expression of sIL-2R is induced by mononuclear cell activation [1, 2]; especially, activated T cells are known to be the main inducer of sIL2R. The upper limit of the normal range of sIL-2R is approximately 500 U/ml. On the other hand, serum lactate(More)