Rik Roelandts

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BACKGROUND Photoallergic contact dermatitis from topical ketoprofen (KP), a nonsteroidal anti-inflammatory agent, is a well-known side effect. OBJECTIVES To investigate photo-contact allergic reactions to KP and other nonsteroidal anti-inflammatory drugs (NSAIDs), sunscreens, and fragrance components as well as the presence of prolonged photosensitivity(More)
Photodynamic therapy (PDT) is a treatment option particularly well-suited for superficial (pre)malignant skin lesions due to the skin's accessibility to light. In the present study, the efficacy of topical hypericin-PDT was evaluated using a mouse model for actinic keratosis. For comparison, similar experiments were conducted with methyl-aminolevulinic acid(More)
Hypericin, a naturally occurring photosensitizer, is currently being investigated for topical use in photodynamic therapy (PDT). In a previous study, it was found that hypericin can be delivered in the epidermis of hairless mouse skin after a 4-h application in Beeler base. With the intention to further optimize the penetration conditions, the present study(More)
Hypericin is a photo-active dye originating from the St. John's wort. Two patients with disseminated superficial actinic porokeratosis (DSAP) were treated with photodynamic therapy (PDT) using topical hypericin. Although a partial response was obtained in one patient topical hypericin-PDT does not emerge as a promising treatment for DSAP.
This multicentre, randomized study compared photodynamic therapy using topical methyl aminolaevulinate (MAL PDT), a non-invasive modality, with cryotherapy for treatment of superficial basal cell carcinoma. Sixty patients with 114 lesions were treated with MAL cream (160 mg/g) applied for 3 hours before illumination (570-670 nm, light dose 75 J/cm) (1(More)
Phototherapy has a very long, albeit mostly anecdotal history. Real interest in the use of ultraviolet irradiation in the treatment of various diseases started in the 19th century and reached a climax when Niels Finsen received the Nobel Prize in 1903 for his therapeutic results with lupus vulgaris. This marked the start of modern phototherapy. It was used(More)
BACKGROUND Hypericin, originating from Hypericum perforatum, is a potent photosensitizer known to induce skin phototoxicity when given systemically. Previously, we have examined the penetration and distribution of hypericin and its acetate ester in the skin of hairless mice after topical application. OBJECTIVES In this study, we assessed the time course(More)
Phototherapy and photochemotherapy (PUVA therapy) have revolutionized the treatment of many photodermatoses and can offer photosensitive patients an improved quality of life. This is especially the case for polymorphic light eruption, chronic actinic dermatitis, erythropoietic protoporphyria and solar urticaria.
The data in the literature regarding the carcinogenic risks involved in both UVB phototherapy and 8-methoxypsoralen plus UVA photochemotherapy are discussed. Both modes of treatment can be mutagenic and can induce immunosuppression. Which of the two factors (the initiator or the promoter effect) is more responsible for the carcinogenic risks involved in(More)