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teroscopy system (Olympus Medical Systems Europa GmbH, Hamburg, Ger− many; l" Fig. 1) consists of a high−resolu− tion endoscope (XSIF−Q160Y) with a working length of 200 cm, and an outer diameter of 9.2 mm, and a flexible over− tube (XST−BY3A; l" Fig. 2) with a working length of 132 cm and an outer diameter of 13.2 mm. A latex−free balloon is only attached(More)
The liver plays a central role in the maintenance of homeostasis and health in general. However, there is substantial inter-individual variation in hepatic gene expression, and although numerous genetic factors have been identified, less is known about the epigenetic factors. By analyzing the methylomes and transcriptomes of 14 fetal and 181 adult livers,(More)
BACKGROUND Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous disorder that can be an autosomal-dominant, autosomal-recessive, or X-linked disease. The most common autosomal-dominant form of the disease derives from mutations in the SPAST gene. METHODS The aim of this study was to analyze 49 patients diagnosed with HSP from(More)
The epitaxial growth of the SmCo/sub 5/ phase and the possibility for obtaining a homogenous film with improved magnetic properties compared to the epitaxial Sm/sub 2/Co/sub 7/ films were explored. Pulsed laser deposition (Kr-F excimer laser) from elemental targets was used to obtain these films on single crystal MgO(100) substrates with Cr buffers. Film(More)
BACKGROUND Thiopurine methyltransferase (TPMT) is a cytoplasmic enzyme involved in the metabolism of thiopurine drugs. To date, at least 25 single nucleotide polymorphisms have been reported in the TPMT gene, 23 of these are associated with reduced enzyme activity. METHODS The aim of the present study was to sequence the whole coding region of TPMT (exons(More)