Riidiger Schade

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A new isolation procedure of rat C-reactive protein (CRP) by affinity chromatography on aminocoupled phosphorylcolamine-Sepharose is described. CRP serum level of rats injured by turpentine injection or two different arthritis models was determined to test the potency of this protein as an marker of inflammation. The influence of repeated adminstration of(More)
During 6-sulphanilamidoindazole (6-SAI) arthritis a significant increase of serum levels of the protease inhibitor α2 macroglobulin (= α2 acute phase globulin) and of Darey's glycoprotein was found, whereas the content of female specific protein and of sulfhydryl groups was proved to be significantly decreased. Intravenous administration of 5 mg/kg soybean(More)
The anti-inflammatory effect of dexamethasone in carrageenin paw edema and in adjuvant arthritis of rats was not influenced by simultaneous injection of RNA/protein synthesis inhibitors. The increase of the plasma alpha 2-microglobulin level during adjuvant arthritis was significantly reduced after administration of RNA/protein synthesis inhibitors. This(More)
The original view of glucocorticoid effects as being divided into physiological and pharmacological ones is no longer acceptable, i.e. all glucocorticoid effects are apparently mediated by receptor occupation which triggers RNA/protein synthesis. The concentrations needed for receptor-mediated effects are low, e.g. theK D value for dexamethasone is in the(More)
Arthritis induced by 6-sulphanilamidoindazole in older rats is not inhibited by a one-week treatment with superoxide dismutase, peroxidase or desferrioxamine. It is concluded that oxygen radicals hardly play a special part in the pathogenesis of 6-SAI arthritis. C-reactive protein and caeruloplasmin are demonstrated to be acute-phase reactants also in 6-SAI(More)
The acute phase response can be modulated by glucocorticoids and catecholamines as well. We treated Wistar rats with either epinephrine or different selective or non-selective beta-agonists in combination with beta-antagonists. The alpha 2-acute phase globulin (alpha 2-APG) serum concentrations were examined by means of electroimmunodiffusion 24 hours after(More)
The concentrations of cholecystokinin (CCK) and dopamine (DA) were determined in the nucleus accumbens (anterior, posterior) and striatum of rats every 2 h during a period of 24 h. For both substances, a circadian rhythm was found, which was best fitted by a dominant 24-h period superimposed by the second (12 h) and fourth (6 h) harmonics. The rhythms in(More)
The alpha-2-acute phase globulin (alpha 2-APG) of the rat is one of the best investigated acute phase proteins. Glucocorticoids as well as catecholamines could be characterized as potent modulators of alpha 2-APG concentration. The aim of this study was to investigate whether the C-reactive protein (CRP), another acute phase protein important in human(More)
Due to contrary results concerning the interaction of cholecystokinin and dopamine (CCK/DA) circadian variations in CCK/DA concentration were investigated in forebrain nuclei of rats (Nc. accumbens, striatum) in order to assess the influence of time of day on neurotransmission. CCK was determined by a radioimmunoassay, DA was measured by electrochemical(More)