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  • Y Iwasaki, J M Chong, +6 authors M Fukayama
  • Journal of virology
  • 1998
A transplantable human Epstein-Barr virus-associated gastric carcinoma (EBVaGC), designated KT, was propagated in severe combined immunodeficiency (SCID) mice for 12 passages. Mucin and cytokeratin expression and the Alu sequence in tumor DNA confirmed that the KT tumor was derived from human epithelial tissue. The identity of clonal EBV in the original and(More)
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Since c-kit mutation occurs only in one-third of GIST, there might be other molecular mechanisms. Loss of heterozygosity (LOH), microsatellite instability (MSI) and NF2 gene mutation were investigated in 22 GISTs (9 low-risk and 13 high-risk tumors).(More)
p300 is a transcriptional coactivator, and bi-allelic mutations of the p300 gene have been demonstrated in human cancers. In 80 gastric carcinoma tissues, loss of heterozygosity (LOH) was analyzed by polymerase chain reaction (PCR) analysis, using 14 primer pairs at the 22q11–13 locus con-taining NF2 and p300. The mutations of the p300 gene were examined by(More)
Clonality and genetic abnormalities were evaluated to characterize proliferative lesions of the parathyroid gland. Fourteen lesions from patients with single-gland proliferation (adenomas [PA]), 6 lesions from patients with multiple-gland proliferation (primary hyperparathyroidism [PHPT]), and 47 lesions from 16 patients with secondary hyperparathyroidism(More)
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