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  • Mai Quỳnh Nguyễn, Richard C. Marcellus, +14 authors Gordon C. Shore
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2007 (First Publication: 4 December 2007)
  • Elevated expression of members of the BCL-2 pro-survival family of proteins can confer resistance to apoptosis in cancer cells. Small molecule obatoclax (GX15-070), which is predicted to occupy aExpand
  • A. Ruefli, M. Ausserlechner, +5 authors R. Johnstone
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2001 (First Publication: 4 September 2001)
  • Many chemotherapeutic agents induce mitochondrial-membrane disruption to initiate apoptosis. However, the upstream events leading to drug-induced mitochondrial perturbation have remained poorlyExpand