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The purpose of the present study was to test the hypothesis that alterations in nerve impulse traffic can influence the activity of substances which act prejunctionally to alter adrenergic neurotransmission. Measurements of the rapid phasic contraction of the isolated rat or guinea-pig vas deferens to short periods of electrical field stimulation were(More)
Inadequate selection of the dose to bring forward in confirmatory trials has been identified as one of the key drivers of the decreasing success rates observed in drug development programs across the pharmaceutical industry. In recognition of this problem, the Pharmaceutical Research and Manufacturers of America (PhRMA), formed a working group to evaluate(More)
Pregnant female ICR mice were administered, ip, either a trace (200 muCi/kg) or teratogenic (200 muCi + 300 mg/kg) dose of [6(-3)H] 5-iododeoxyuridine (IdU) on day 10 of gestation. Maternal liver, spleen, intestine, and kidneys, and placentas and embryos were removed at various time intervals after injection, weighed, and homogenized in cold 0.5 m(More)
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