Three acutely psychotic patients with psychomotor excitement and agitation were rapidly sedated following intramuscular injections of 2.5 mg to 3 mg of midazolam. The use of midazolam, a short- and rapid-acting benzodiazepine preparation, in a psychiatric emergency room setting is discussed.
Schizophrenia is a genetically complex illness with heterogeneous clinical presentation, including variable age of onset. In this study, the heritability, or proportion of variation in age of onset of psychotic symptoms due to genetic factors, was estimated using a maximum likelihood method. The subjects were 717 members of families with more than one… (More)
There is ample evidence attesting to differences in drug response and disposition among certain ethnic groups. The existing body of knowledge concerning pharmacological issues in the Hispanic and Native American ethnic groups, however, is both meager and confusing. In this article, the authors first attempt to briefly characterize these increasingly… (More)
Schizophrenia is a complex psychiatric disorder, likely to be caused in part by multiple genes. In this study, linkage analyses were performed to identify chromosomal regions most likely to be associated with schizophrenia and psychosis in multiplex families of Mexican and Central American origin. Four hundred and fifty-nine individuals from 99 families,… (More)
The last decade has witnessed substantial progress in our understanding of ethnic differences and similarities between Asians and other ethnic groups in response to various psychotropics. Capitalizing on recent advances in cross-cultural and psychobiological research methodology, a number of recent studies have suggested a special sensitivity of Asians to… (More)
OBJECTIVE Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. METHOD We evaluated whether genetic variation in 5-HTTLPR, influences current depression, lifetime history of depression and quantitative measures of depression in… (More)
Although striking ethnic differences in pharmacologic responses to various medications have been documented in the general medical literature, there is a paucity of such information in the psychopharmacologic literature. Recent work has provided a number of studies that illustrate interesting inter-ethnic pharmacogenetic, pharmacokinetic, and… (More)