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Transforming growth factor (TGF)-beta is growth inhibitory for normal epithelial cells and melanocytes but can stimulate mesenchymal cells. Resistance to its inhibitory effects is characteristic of human melanoma, the growth of which may instead be promoted by TGF-beta, because its production is increased with melanoma progression. Whether TGF-beta has an(More)
Exposure to UV radiation likely plays a key role in melanoma development , whereas other etiologic agents remain unknown. Here we show that in normal human skin an increased expression of a combination of three growth factors, basic fibroblast growth factor, stem cell factor, and endothelin-3, along with exposure to UVB can transform normal melano-cytes(More)
BACKGROUND We investigated the radiographic parameters that may predict distal radial ulnar joint (DRUJ) instability in surgically treated radial shaft fractures. In our clinical experience, there are no previously reported radiographic parameters that are universally predictive of DRUJ instability following radial shaft fracture. MATERIALS AND METHODS(More)
A fracture construct, representing a worst-case model of a comminuted intertrochanteric fracture, was created in order to compare the fixation stability of two different cephalomedullary nails: one where the lag screw can telescope within itself to achieve displacement of the head-neck fragment, and the other where the solid lag screw slides only. After(More)
The purpose of this study was to compare fixation stability and lag screw sliding characteristics between 2 different hip-nail lag screw designs, a telescoping screwbarrel and a solid helical blade. Simulated, unstable, 4-part intertrochanteric hip fractures were created in 6 pairs of cadaveric femurs. Each nail type was randomly assigned within each femur(More)
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