Richard Willingale

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We present a detailed X-ray spectral analysis of Cas A using a deep exposure from the EPIC-MOS cameras on-board XMM-Newton. Spectral fitting was performed on a 15×15 grid of 20 ′′ × 20 ′′ pixels using a two component non-equilibrium ionisation model (NEI) giving maps of ionisation age, temperature, interstellar column density, abundances for Ne, Mg, Si, S,(More)
We have developed a technique for analysing blood plasma using MALDI-MS with subsequent data analysis to identify significant and specific differences between heart failure (HF) patients and healthy individuals. A training dataset comprising 100 HF patients and 100 healthy individuals was used to search for biomarkers (m/z range 1000-10,000). EWP cartridges(More)
Membrane domains rich in caveolin-3 overlie sarcomeric actin in skeletal muscle. The membrane exhibits a regular array of caveolin-3 immunofluorescence using confocal laser scanning microscopy (CLSM). Fourier analysis of tissue imaged by CLSM accurately defines a repeating intensity with a long-axis spacing of 1.48 microm confirmed by measurement of direct(More)
Gamma-ray bursts (GRBs) come in two classes: long (> 2 s), soft-spectrum bursts and short, hard events. Most progress has been made on understanding the long GRBs, which are typically observed at high redshift (z approximately 1) and found in subluminous star-forming host galaxies. They are likely to be produced in core-collapse explosions of massive stars.(More)
We present the first results on the hard X-ray continuum image (up to 15 keV) of the supernova remnant Cas A measured with the EPIC cameras onboard XMM-Newton. The data indicate that the hard X-ray tail, observed previously, that extends to energies above 100 keV does not originate in localised regions, like the bright X-ray knots and filaments or the(More)
  • N R Tanvir, D B Fox, +60 authors C Wolf
  • 2009
Long-duration gamma-ray bursts (GRBs) are thought to result from the explosions of certain massive stars, and some are bright enough that they should be observable out to redshifts of z > 20 using current technology. Hitherto, the highest redshift measured for any object was z = 6.96, for a Lyman-alpha emitting galaxy. Here we report that GRB 090423 lies at(More)
The study of the early high-energy emission from both long and short Gamma-ray bursts has been revolutionized by the Swift mission. The rapid response of Swift shows that the non-thermal X-ray emission transitions smoothly from the prompt phase into a decaying phase whatever the details of the light curve. The decay is often categorized by a(More)
The long burst GRB 050717 was observed simultaneously by the Burst Alert Telescope (BAT) on Swift and the Konus instrument on Wind. Significant hard to soft spectral evolution was seen. Early gamma-ray and X-ray emission was detected by both BAT and the X-Ray Telescope (XRT) on Swift. The XRT continued to observe the burst for 7.1 days and detect it for 1.4(More)
Discovery of protein biomarkers in clinical samples necessitates significant prefractionation prior to liquid chromatography-mass spectrometry (LC-MS) analysis. Integrating traveling wave ion mobility spectrometry (TWIMS) enables in-line gas phase separation which when coupled with nanoflow liquid chromatography and data independent acquisition tandem mass(More)
We show that all X-ray decay curves of GRBs measured by Swift can be fitted using one or two components both of which have exactly the same functional form comprised of an early falling exponential phase followed by a power law decay. The 1st component contains the prompt γ-ray emission and the initial X-ray decay. The 2nd component appears later, has a(More)