Learn More
Chronic fatigue syndrome (CFS) is a serious systemic illness of unknown cause. A recent study identified DNA from a xenotropic murine leukemia virus-related virus (XMRV) in peripheral blood mononuclear cells (PBMCs) from 68 of 101 patients (67%) by nested PCR, as compared with 8 of 218 (3.7%) healthy controls. However, four subsequent reports failed to(More)
Today's data centers host online services on multiple servers, with a front-end load balancer directing each client request to a particular replica. Dedicated load bal-ancers are expensive and quickly become a single point of failure and congestion. The OpenFlow standard enables an alternative approach where the commodity network switches divide traffic(More)
All rights reserved. Short sections of text, not to exceed two paragraphs, may be quoted without explicit permission, provided that full credit including © notice is given to the source. Abstract-To fight terrorism successfully, the quality of data must be considered to avoid garbage-in-garbage-out. Research has shown that data quality (DQ) goes beyond(More)
Recent research in information quality management concluded that firms must manage information as a product, and that the entire information manufacturing system must be managed in order to enable firms to assure delivery of information products with high quality. In this paper, we report a longitudinal case study in a major hospital on how data production(More)
MOTIVATION As the use of microarrays in human studies continues to increase, stringent quality assurance is necessary to ensure accurate experimental interpretation. We present a formal approach for microarray quality assessment that is based on dimension reduction of established measures of signal and noise components of expression followed by parametric(More)
An increasing number of wearable and mobile devices are capable of automatically sensing and recording rich information about the surrounding environment. To make use of such data, it is desirable for each data point to be matched with its corresponding spatial location. We focus on using the trajectory from a device's odometry sensors that reveal changes(More)
OBJECTIVE Genetic approaches have identified numerous loci associated with coronary heart disease (CHD). The molecular mechanisms underlying CHD gene-disease associations, however, remain unclear. We hypothesized that genetic variants with both strong and subtle effects drive gene subnetworks that in turn affect CHD. APPROACH AND RESULTS We surveyed(More)
SEN virus (SENV) has been tentatively linked to transfusion-associated non-A-E hepatitis. We investigated SENV's role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV was detected in 54 (22%) of 248 patients with acute or(More)