Richard W. Taylor

Learn More
The carboxylic acid ionophore monensin, known as an electroneutral Na(+) ionophore, an anticoccidial agent, and a growth-promoting feed additive in agriculture, is shown to be highly efficient as an ionophore for Pb(2+) and to be highly selective for Pb(2+) compared with other divalent cations. Monensin transports Pb(2+) by an electroneutral mechanism in(More)
Among divalent cations, the ionophore monensin shows high activity and selectivity for the transport of lead ions (Pb2+) across phospholipid membranes. When coadministered to rats that were receiving meso-dimercaptosuccinate for treatment of Pb intoxication, monensin significantly increased the amount of Pb removed from femur, brain, and heart. It showed a(More)
The K(+) ionophore nigericin is shown to be highly effective as an ionophore for Pb(2+) but not other divalent cations, including Cu(2+), Zn(2+), Cd(2+), Mn(2+), Co(2+), Ca(2+), Ni(2+), and Sr(2+). Among this group a minor activity for Cu(2+) transport is seen, while for the others activity is near or below the limit of detection. The selectivity of(More)
This paper describes how, through a combination of scheduling and bu er insertion, real-time systems may be optimized for power consumption while maintaining deadlines. Beginning with simple examples (components that have no internal pipelines and in which the only design freedoms are bu er insertion and scheduling), we illustrate the e ect of adjusting the(More)
The benzoannelated diazapolyether macrocycles 6,7,9,10,17,18-hexahydro-5H,11H-8,16,19-trioxa-5,11-diazadibenzo[a,g]cyclopentadecene, C(18)H(22)N(2)O(3), (I), 6,7,9,10,12,13,20,21-octahydro-5H,14H-8,11,19,22-tetraoxa-5,14-diazadibenzo[a,g]cyclooctadecene, C(20)H(26)N(2)O(4), (II), and(More)
The macrobicyclic title compound, C(24)H(28)N(2)O(7), has two tertiary diamide bridgehead atoms and is composed of a 12-membered ring (N(2)O(2) donor set) and two 18-membered rings (N(2)O(4) donor sets). The solid-state structure shows that each of the amide groups is not coplanar with the adjacent benzene ring and NMR studies indicate that this(More)