Richard W Sapp

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During critical periods of development, the brain easily changes in response to environmental stimuli, but this neural plasticity declines by adulthood. By acutely disrupting paired immunoglobulin-like receptor B (PirB) function at specific ages, we show that PirB actively represses neural plasticity throughout life. We disrupted PirB function either by(More)
Synapse pruning is an activity-regulated process needed for proper circuit sculpting in the developing brain. Major histocompatibility class I (MHCI) molecules are regulated by activity, but little is known about their role in the development of connectivity in cortex. Here we show that protein for 2 MHCI molecules H2-Kb and H2-Db is associated with(More)
Previous studies from this laboratory (17, 19) have demonstrated that methyl, chioro, or nitro groups in the @†̃, 3', or 4' positions of the hepatic carcinogen, 4-dimethylaminoazobenzene, pro duced parallel alterations in the carcinogenicity of this dye. In each series the 4'-isomer was the least active and the 3'-isomer was the most active. Fur thermore,(More)
Synapse density on cortical pyramidal neurons is modulated by experience. This process is highest during developmental critical periods, when mechanisms of synaptic plasticity are fully engaged. In mouse visual cortex, the critical period for ocular dominance (OD) plasticity coincides with the developmental pruning of synapses. At this time, mice lacking(More)
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