Richard W. Lee

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BACKGROUND The mechanisms by which mandibular advancement splints (MAS) improve obstructive sleep apnoea (OSA) are not well understood. This study aimed to evaluate the mechanism of action of MAS by assessing their effect on upper airway structure in patients with OSA. METHODS Patients were recruited from a sleep disorders clinic for treatment with a(More)
STUDY OBJECTIVES To compare the craniofacial morphological phenotype of subjects with and without obstructive sleep apnea (OSA) using a quantitative photographic analysis technique. DESIGN Case-control study; subgroup matched for body mass index (BMI) and sex. SETTING Sleep investigation unit in a university teaching hospital. PATIENTS 114 subjects(More)
STUDY OBJECTIVES To develop models based on craniofacial photographic analysis for the prediction of obstructive sleep apnea (OSA). DESIGN Prospective cohort study. SETTING Sleep investigation unit in a university teaching hospital. PATIENTS One hundred eighty subjects (95.6% Caucasian) referred for the initial investigation of OSA were recruited(More)
STUDY OBJECTIVES To explore differences in craniofacial structures and obesity between Caucasian and Chinese patients with obstructive sleep apnea (OSA). DESIGN Inter-ethnic comparison study. SETTING Two sleep disorder clinics in Australia and Hong Kong. PATIENTS 150 patients with OSA (74 Caucasian, 76 Chinese). INTERVENTIONS Anthropometry,(More)
Oral appliances for the treatment of obstructive sleep apnea (OSA) are worn during sleep to maintain the patency of the upper airway by increasing its dimensions and reducing its collapsibility. Oral appliances are a simpler alternative to continuous positive airway pressure (CPAP). Over the last decade, there has been a significant expansion of the(More)
We describe a new variant of transient left ventricular (LV) ballooning in North American Caucasian patients in which only the midventricle is affected. The patients described in this case series initially presented with emotional or physical stress and had similarities to transient apical ballooning syndrome; however, this variant is unique in that the(More)
The cardiovascular system of hypothyroid, normal, and hyperthyroid rats was studied by evaluation of the peripheral venous circulation and left ventricular (LV) systolic and diastolic performance in rats. Cardiac index (CI) and CI during a volume load were measured in open-chest rats. When compared with control, hypothyroid rats showed a decrease in heart(More)
Percutaneous interventions for symptomatic chronic mesenteric arterial atherosclerosis are rapidly gaining popularity. This study evaluates the long-term anatomic and functional outcomes of endovascular therapy for chronic atherosclerotic occlusive mesenteric arterial disease at a tertiary referral academic medical center. A retrospective analysis of(More)
Accumulating data suggest that endovascular repair (EVAR) of ruptured abdominal aortic aneurysms (RAAAs) leads to reduced mortality, but concern exists that this may reflect selection bias. We reviewed our overall rupture experience early after our protocol was instituted to explore this question. We instituted a defined protocol for RAAA with emphasis on(More)
Although positive airway pressure is the most efficacious treatment for obstructive sleep apnea (OSA), its clinical effectiveness is limited by its obtrusive interface. Two alternative treatment modalities used in clinical practice are mandibular advancement devices (MADs) and positional therapy. The goals in treatment of OSA are to prevent obstructive(More)